| Abstract: | Two reports indicate that some women may experience a mild adverse effect on milk yield. Variable effects of DMPA (depot medroxyprogesterone acetate) on breast milk composition have been reported. Different studies have reported increased, unchanged, or decreased milk concentrations or total contents of lactose, protein or lipid. Another study has indicated a minor depressive effect on development. Recent evidence suggests that milk concentrations of MPA may be as high as maternal plasma levels and transfer of DMPA may be appreciable. There is some concern that DMPA may have small effects on growth, maturation and subsequent reproductive function of the neonate. Sammour's study reported a 16% decrease in protein count in milk. Another study shows a 48% decrease in protein. Since reduced protein concentrations mean reduced immunoglobulins, the infant's prime protection against early death, it is a disservice to publicize a conclusion stating that progestogens do not adversely affect milk production and composition. |
