| 大鼠局灶脑缺血再灌注后GM1的保护作用及其对FGFR1表达的影响 |
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| 引用本文： | 赵传胜,王慕一,高旭光,关明.大鼠局灶脑缺血再灌注后GM1的保护作用及其对FGFR1表达的影响[J].中风与神经疾病杂志,1999,16(1):9-11. |
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| 作者姓名： | 赵传胜 王慕一 高旭光 关明 |
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| 作者单位： | 1. 110001,沈阳,中国医科大学一院神经内科
2. 满洲里市第一医院 |
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| 摘 要： | 目的 探讨大鼠局灶脑缺血再灌注后神经节苷脂（ＧＭ１）的保护作用及其对碱性纤维母细胞生长因子的特异性受体（ＦＧＦＲ１）表达的影响。方法 采用检线法备大脑中动脉缺血再灌注模型。通过腹腔注射给予ＧＭ１，利用免疫组化方法检测ＦＧＦＲ１表达情况，并对病理学改变进行观察研究。结果 与对照组相比，缺血再灌组ＦＧＦＲ１表达明显增多（Ｐ〈０．０１），而ＧＭ１用药组与缺血再灌组相比，ＦＧＦＲ１表达也明显增长（Ｐ〈０．
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| 关 键 词： | 脑缺血 FGFR 大鼠 神经节苷脂 再灌注损伤 |
Protective function of GM1 after cerebral ischemic reperfusion and effect on the expression of FGFR1 |
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| Zhao Chuansheng, Wang Muyi, Gao Xuguang,et al..Protective function of GM1 after cerebral ischemic reperfusion and effect on the expression of FGFR1[J].Journal of Apoplexy and Nervous Diseases,1999,16(1):9-11. |
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| Authors: | Zhao Chuansheng Wang Muyi Gao Xuguang |
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| Institution: | Zhao Chuansheng, Wang Muyi, Gao Xuguang, et al. |
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| Abstract: | Objective To study the protective function of GM1 after cerebral ischcmic reperfusionand effect on the expression of FGFR1. Methods We made the local cerebral ischemic reperfusion model with thread embolism of middle cerebral artery. Immunostaining was used to study the expression ofFGFR1. Results The expression of FGFR1 in ischemic reperfusion group was significantly increased ascompared with control group. Furthermore,FGFR, expression of GM, group was significantly increasedas compared with ischemic reperfusion group. The pathological changes was also lighter than that of ischemic group. Conclusion GM1 has significantly cerebral protective effect and can induce upregulationof FGFR1 expression. |
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| Keywords: | GM1 Cerebral ischemic reperfusion FGFR1 |
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