| B7-同系物1分子的免疫功能及其在疾病中的作用 |
| |
| 引用本文： | 陈良恩,王福生. B7-同系物1分子的免疫功能及其在疾病中的作用[J]. 医学研究生学报, 2007, 20(7): 754-758 |
| |
| 作者姓名： | 陈良恩 王福生 |
| |
| 作者单位： | 1. 军事医学科学院放射医学研究所,北京,100850;空军航空医学研究所,北京,100036
2. 解放军第三0二医院传染病研究所,北京,100039 |
| |
| 摘 要： | B7同系物1（B7-H1）分子是共刺激分子B7家族的重要成员,在淋巴细胞及大部分外周组织可以广泛诱导性表达.B7-H1可以和T、B细胞上程序性死亡-1（PD-1）受体及另一未知的刺激性受体结合,调节淋巴细胞的功能.B7-H1分子的表达与肿瘤、炎症、器官移植排斥以及病毒感染等疾病密切相关.通过调控B7-H1的表达水平来调节淋巴细胞的免疫功能,将为疾病的免疫治疗提供新的思路.
|
| 关 键 词： | B7同系物1 程序性死亡-1 |
| 文章编号： | 1008-8199（2007）07-0754-05 |
| 收稿时间： | 2005-08-30 |
| 修稿时间： | 2005-08-302006-01-08 |
Immunological effect and function of B7-homolog1 on diseases |
| |
| CHEN Liang-en,WANG Fu-sheng. Immunological effect and function of B7-homolog1 on diseases[J]. Bulletin of Medical Postgraduate, 2007, 20(7): 754-758 |
| |
| Authors: | CHEN Liang-en WANG Fu-sheng |
| |
| Affiliation: | 1. Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China; 2. Institute of Aviation Medicine, Airforce PLA, Beijing 100036, China; 3. Institute of Infection Diseases, the 302 Hospital of PLA, Beijing 100039, China |
| |
| Abstract: | B7-homolog1(B7-H1) is one of the important members of costimulatory molecules B7 family and broadly induced in the majority of peripheral tissues as well as lymphocyte.Upon binding to programmed death 1 receptors and an as yet unidentified costimulatory receptor on T-cells and B-cells,B7-H1 may regulate lymphocyte responses in peripheral tissues.The negative regulatory role of B7-H1 has also been documented in human diseases,including cancer,inflammation,allograft rejection,and virus infection.Delineation of the complex interactions between B7-H1 and its receptors as well as its interplay with other ligands is critical for understanding this new immunoregulatory system.Precise manipulation of B7-H1 and its receptors may provide unique opportunities for designing new disease treatments. |
| |
| Keywords: | B7-homologl PD-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
