A Multicenter Phase II Study of Docetaxel 60 mg/m2 as First-Line Chemotherapy in Patients with Advanced or Recurrent Breast Cancer |
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Authors: | Takashi Ishikawa Satoru Shimizu Masaaki Inaba Taro Asaga Kiyohumi Katayama Mamoru Fukuda Yutaka Tokuda Kazuo Ishida Eisuke Fukuma Takashi Suda Yohei Hamaguchi Akira Ishiyama Hiroshi Shimada |
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Affiliation: | Department of General Surgery, Yokohama City University Medical Center, Minami-ku, Yokohama 232-0024, Japan. tishik@urahp.yokohama-cu.ac.jp |
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Abstract: | PURPOSE: Docetaxel is an active agent as first-line chemotherapy in patients with advanced breast cancer at a dosage of 100 mg/m2. However, the efficacy of this agent as a first-line drug when used at a lower dosage is unclear. This study was performed to evaluate the clinical efficacy and safety of 60 mg/m2 docetaxel for the treatment of breast cancer. PATIENTS AND METHODS: This study enrolled 23 patients with advanced and/or metastatic breast cancer, who had not been treated with an anthracycline or taxane previously. Treatment with docetaxel was continued in patients showing a response until there was evidence of disease progression or unacceptable toxicity. RESULTS: Among 20 fully evaluated patients, the overall response rate was 50.0% and the median time to progression was 31 weeks. The most commonly observed adverse events were neutropenia (78.2%) and fatigue (60.9%). Fluid retention occurred in only 8.7% of the patients. Adverse events did not cause discontinuation of the treatment. CONCLUSION: Docetaxel achieved good disease control with mild adverse events in first-line treatment at a dosage of 60 mg/m2. |
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Keywords: | Advanced breast cancer First-line chemotherapy Docetaxel |
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