| 重组人表皮生长因子对大鼠皮肤烧伤愈合的促进作用 |
| |
| 引用本文： | 缪世坤,彭波,杨云霞,朱玲,冯云,范爱兰.重组人表皮生长因子对大鼠皮肤烧伤愈合的促进作用[J].四川生理科学杂志,2007,29(3):107-108. |
| |
| 作者姓名： | 缪世坤 彭波 杨云霞 朱玲 冯云 范爱兰 |
| |
| 作者单位： | 四川大学基础医学与法医学院,四川成都,610041;中山大学生命科学院动物生理教研室,广州,5102750 |
| |
| 摘 要： | 目的:观察局部应用重组人表皮生长因子(recombined human epidermal growth factor,rhEGF)对大鼠皮肤深Ⅱ度烧伤有无促进作用.方法:建立约10%的大鼠烧伤面积,测定给不同剂量的rhEGF治疗后不同时间的烫伤创面愈合面积,创面组织病理组织学以及测定愈合时间来观察rhEGF对皮肤创伤的治疗作用.结果: rhEGF小、中、大剂量(每cm2创面200 IU,400 IU,800 IU)可以缩短大鼠皮肤深Ⅱ度烧伤愈合的时间,同一时间内烧伤愈合面积高于对照组,同时还可以增加表皮细胞和毛细血管的增生,三个剂量之间未见明显的量效反应.结论:局部应用rhEGF可以促进大鼠皮肤烧伤愈合.
|
| 关 键 词： | 重组人表皮细胞生长因子 烧伤 愈合 大鼠 |
| 修稿时间： | 2007年6月10日 |
Study of recombined human epidermal growth factor(rhEGF)improving experimental wound healing in rats |
| |
| Miu Shi-kun,Peng Bo,Yang Yun-xia,Zhu Ling,Feng Yun,Fan Ai-lan.Study of recombined human epidermal growth factor(rhEGF)improving experimental wound healing in rats[J].Sichuan Journal of Physiological Sciences,2007,29(3):107-108. |
| |
| Authors: | Miu Shi-kun Peng Bo Yang Yun-xia Zhu Ling Feng Yun Fan Ai-lan |
| |
| Abstract: | Objective:The effect of the topical application of recombined human epidermal growth factor(rhEGF) on healing of burn wound in rat was evaluated.Methods:Time to complete healing,the healing areas,and cell growth were the measured parameters.Results:Topical application of rhEGF(200 IU,400 IU,800 IU per cm2 burn wound)to rat burnt wound deceased the time to complete healing,increased healing areas and accelerated reepithelialization.Conclusion:We were able to demonstrate an insignificant healing advantage with the topical application of EGF. |
| |
| Keywords: | Recombined human epidermal growth factor Burn Wound healing Rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
