胰腺癌并肝转移的临床病理学特点分析

对345例胰腺癌患者中68例经手术、病理及影像诊断学证明为肝转移的胰腺癌患者,进行临床病理学资料分析。40岁以下者肝转移率13.80%。同期>40岁者肝转移率21.10%,两组差异有统计学意义,P=0.037。全胰腺癌,肝转移率22.60%,与胰头、颈部、体及胰尾比较差异有统计学意义,P=0.005。高中分化癌与低分化癌两组肝转移率分别为8.65%和55.96%,两组差异有统计学意义,P=0.05。有、无肝转移的血管受侵率分别为44.10%和30.30%,两组差异有统计学意义,P=0.003。有淋巴结转移的胰腺癌组肝转移率为23.50%,无淋巴结转移的胰腺癌组肝转移率为18.10%,两组差异有统计学意义,P=0.033。胰腺癌局限在胰内者,肝转移率10.59%,胰腺癌侵及胰腺周围者,肝转移率32.00%,两组比较差异有统计学意义,P=0.005。初步研究结果提示,胰腺癌肝转移与胰周血管受侵、淋巴结转移及病理分化程度密切相关。

Analysis of clinicopathological characteristics of pancreatic tumor with liver metastasis

The 68 patients among 345 patients with pancreatic tumor were confirmed to metastasize to liver. The liver metastasis rate in patients who were not elder than 40-year-old was 13.80%. The patients elder than 40-year-old the rate was 21.10%, and there was a significant difference between them (P=0.037). The rate of liver metastasis in total pancreatic tumor was 22.60%, which was significantly different from that in head, neck, body or tail of pancreatic tumor. The liver metastasis rates of well and poorly differentiated tumors were 8.65% and 55.96% respectively,P=0.005. Vessel invasion rate of tumor with liver metastasis was much higher than that of one without liver metastasis,P=0.003. The rate of pancreatic tumor with lymph nodes metastasis was 23.50%, on the contrary, the rate was 18.10% in patients without metastasis, P=0.033. Pancreatic tumor cells merely existed in pancreatic tissue, the of metastasis rate was 10.59%, otherwise, the rate was 32.00% when pancreatic surrounding tissue was involved much more tumor cells,P=0.005. The primary study showed that pancreatic tumor with liver metastasis was closely related to the vessel invasion, lymph nodes metastasis, and differential pathological level.