无痛结肠镜检查应用芬太尼小剂量复合丙泊酚麻醉的可行性分析与不良反应探讨

目的：研究无痛结肠镜检查应用芬太尼小剂量复合丙泊酚麻醉的可行性及不良反应发生情况。方法将我院2011年6～12月收治的50例需进行无痛结肠镜检查的患者作为研究对象;采取芬太尼小剂量复合丙泊酚麻醉方法;观察麻醉效果及不良反应发生情况。结果患者在进行无痛结肠镜检后,收缩压、舒张压、平均动脉压与检查前相比,无明显变化,较为稳定（t=0.4983,0.7552,1.6449;P=0.6183,0.4501,0.1000）;患者检测后,心率、呼吸频率、血氧饱和度稳定,与检测前近似,无统计学差异（t=0.5624,0.8284,1.4926;P=0.5738,0.4075,0.1356）;患者麻醉后,镇静效果较好,平均评分达到（8.94±0.77）分;几乎无疼痛感,疼痛评分为（0.64±0.22）分;术后,仅出现2例恶心呕吐;1例术后腹胀,不良反应率为6.00%。结论无痛结肠镜检查采用芬太尼小剂量复合丙泊酚麻醉后,生命体征稳定,无明显变化,镇静、止痛效果好,且不良反应少,具有一定的临床价值。

Adverse Reaction and Feasibility of Combination of Small Dose Fentanyl and Propofol in Painless Colonoscopy

Objective To study the feasibility and adverse reaction of painless colonoscopy using small dose fentanyl and propofol anesthesia.MethodsChose 50 cases of patients in our hospital from 2011 June ~ December for painless colonoscopy as the research object, took a small dose of fentanyl and propofol anesthesia, observed the anesthetic effect and adverse reaction.Results The systolic pressure, diastolic pressure, mean arterial pressure were compared before and after the examination, there was no obvious changes （t=0.498 3, 1.644 9, P=0.618 3, 0.755 2, 0.450 1, 0.100 0）. After test, the heart rate, respiratory rate, blood oxygen saturation and stability, approximation and detection had no signiifcant difference （t=0.562 4, 1.492 6, P=0.573 8, 0.828 4, 0.407 5, 0.135 6）, after anesthesia, the sedation effect was good, the average score reached to （8.94±0.77）, almost no pain and the pain score was （0.64 ± 0.22）. After the operation, only 2 cases has nausea and vomiting, abdominal distention happened in 1 cases. The adverse reaction rate was 6%.ConclusionPainless colonoscopy using small dose of propofol fentanyl for anesthesia has stable vital signs, no obvious changes and less adverse reaction.