人体内有机物分析及邻苯二甲酸酯含量测定

目的　了解人体内有机物成分及重要有机物的污染水平 ,并评估对人群健康可能产生的危害。方法　采集 50名健康产妇静脉血 ,应用气相色谱 -质谱联用技术 (GC/MS) ,对血液中有机物进行定性检测及重要有机物的定量测定。结果　人体内共检出有机物 158种 ,检出率较高的有机物有 9-十八烯酸 (82 % )、十七烯 -(8)碳酸(66% )、邻苯二甲酸二丁酯 (62 % )、硫代 -(2 -氨基乙基 )硫酸酯 (3 4 % )、14 -β -孕激素 (2 8% )等 ,在检测出的有机物中对检出率较高、具有毒性效应的邻苯二甲酸二丁酯进行定量测定 ,其浓度为 (78 2 9± 3 4 0 1)mg/L。 结论　人体内存在有机物污染 ,部份有机物在人群体中检出率较高 ,其中检出率较高、浓度也较高的邻苯二甲酸二丁酯作为美国环境保护局 (EPA)优先控制污染物 ,具有生殖发育毒性 ,应当引起人们 (特别是育龄期妇女 )的高度重视

Analysis on organic compounds component and determination of phthalate acid esters in human body

ObjectiveTo explore components of organic chemicals and polluted levels of important organic materials in human body,evaluate its potent ial hazard on population health.MethodsThe venous blood specimens from 50 health women w ere collected.Qualitative analysis organic chemicals and quantitative detective important organic materials in venous blood by gas chromatography/mass spectrome ter(GC/MS) after extraction with hexane.Results158 kinds of organic materials were detected from all blood samples,a significantly high frequency of organic chemicals included 9 -Octadecenoic acid (82%),heptadecene-(8)-carbonic acid(66%),di-n-butyl phthalate (62%),thiosulfuric acid (H2S2O3),S-(2-aminoethyl)ester (34%),14-Bate-H-pregna ( 28%),et c.Di-n-butyl phthalate with highly checked out frequency and toxic effec t was determined quantity.ConclusionOrganic pollutants existed in human body and s ome of them were highly checked out.Di-n-butyl phthalate with highly check ed out rate and highly concentration had reproductive developmental toxicity as prority control pollution in USEPA.It would bring about a potential adverse effe ct on population health (for example reproductive toxicity).It should cause our highly attention (special child-bearing period women).