肝硬化患者血清总胆汁酸、胆固醇的检测及其临床意义

目的:探讨肝硬化患者血清总胆汁酸(TBA),胆固醇(CHO)测定与肝功能分级关系。方法:检测80例肝硬化患者与健康人及肝功能分级关系。结果:肝硬化组血清CHO水平低于对照组(P<0.05);而TBA水平高于对照组(P<0.05);在肝硬化组中CHO在C级中最低,与A级和B级比较差异有统计学意义(P<0.05);TBA在A级、B级和C级比较差异有统计学意义(P<0.05),随着肝功能ChildPugh分级的增高而增高。血清TBA在肝硬化早期的阳性率高于其他肝功能指标(P<0.05)。结论:TBA,CHO能敏感反映肝硬化的进展情况。

Serum levels of total bile acids,cholesterol and its clinical significance

Objective To investigate the serum levels of total bile acid （TBA）,cholesterol （CHO） relationship between measured and liver function.Methods The detection of 80 cases of liver cirrhosis patients and healthy relationship between functional class.Results Liver cirrhosis serum CHO level lower than the control group（P0.05）;while TBA was significantly higher（P0.05）;in CHO cirrhosis group the lowest level in C,with A-and B-class comparison There was significant difference（P0.05）;TBA in the A-,B-and C-class was significant difference（P0.05）,with the Child Pugh classification of liver function increased and increased.Serum TBA in early cirrhosis was higher than that of other liver function （P0.05）.Conclusion TBA,CHO can sensitively reflect the progress of liver cirrhosis.