青蒿素及其衍生物纳米制剂在抗肿瘤领域中的研究进展

摘 要青蒿素及其部分衍生物在抗肿瘤方面具有潜在的临床应用价值，但存在水溶性差、半衰期短等缺点，故促使众多学者对其药物制剂进行开发和研究。纳米药物传输系统是一种新型药物递送工具，相比传统的片剂、栓剂、注射剂等，具有稳定性好、靶向释药和联合载药等诸多优点。本文综述了青蒿素类药物的纳米传输载体，包括：纳米粒、脂质体、胶束、纳米微乳和其他纳米载体，概括了青蒿素类药物纳米制剂在肿瘤治疗方面的成果和特点，其中着重介绍青蒿素类药物与转铁蛋白的联合载药递药体系的研究进展。

Research Progress in Nano Preparations of Artemisinin and its Derivatives in Anti tumor Fields

ABSTRACTArtemisinin and its derivatives have shown the potential application value in anti tumor fields. But their applications are limited due to poor solubility, short half life and so on; therefore, many scholars devoted themselves to developing and studying relative pharmaceutical preparations. Nano drug delivery system is a new drug delivery tool. Compared with the traditional dosage forms, such as tablets, suppositories and injections, nano drug delivery system has such advantages as good stability, targeted drug release and combined drug delivery. In this review, nano drug delivery carriers for artemisinin were summarized, including nanoparticles, liposomes, micelles, nanomicroemulsions and so on. The research results and characteristics of artemisinin containing nano formulas in tumor therapy, as well as the co delivery system of artemisinin and transferrin, were discussed.