上皮性卵巢癌患者术前外周血中性粒细胞/淋巴细胞比值在诊断及复发预测中的作用

目的:评价上皮性卵巢癌患者术前外周血中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)在诊断及预测复发中的应用价值.方法:回顾性分析在青岛大学附属医院2003年1月至2011年1月收治的147例良性卵巢肿瘤和134例上皮性卵巢癌(epithelial ovarian cancer,EOC)患者的临床病理资料,通过受试者工作特征曲线确定术前外周血NLR诊断EOC的价值并选取最佳截断值;通过单因素及多因素分析寻找患者5年内复发的高危因素.结果:患者术前NLR对诊断EOC最佳截断值为2.04.术前NLR＜2.04组与NLR≥2.04组患者在年龄、FIGO分期、CA125水平、腹水及淋巴结转移等方面均有明显差异(P＜0.05),而与不同病理类型和分化程度无明显差异(P＞0.05).单或多因素分析结果显示,术前NLR≥2.04为EOC患者术后5年内复发的危险因素(P＜0.05).结论:EOC患者术前NLR升高与癌症的存在及多种临床侵袭性指标相关,是影响EOC患者术后复发的独立危险因素.

Role of peripheral neutrophil/lymphocyte ratio in the diagnosis and recurrenceprediction of epithelial ovarian cancer

Objective:To examine the application value of preoperative blood neutrophil to lymphocyte ratio (NLR) in the diagnosis and recurrence prediction of epithelial ovarian cancer (EOC).Methods:The complete clini cal and pathological information of 147 patients with benign ovarian tumor and 134 patients with EOC that treated in Affiliated Hospital of Qingdao University between January 2003 and January 2011 were retrospectively studied.The optimum cut-off value of the preoperative NLR to diagnose EOC was identified through receiver operator char acteristic (ROC) curve,and the patients were then classified into two groups according to this cut-off value.Univariate and multivariate analyses were performed to assess the high risk factors for the relapse of EOC within 5 years.Results:The optimal cut-off value of NLR was 2.04 to diagnose EOC.There were statistically significant differences in age,CA125 levels,FIGO staging,lymphatic metastasis and ascites formation between the NLR＜2.04 group and the NLR≥2.04 group (P＜0.05),but no significant discrimination was observed in pathological type and differentiation level (P＞0.05).Univariate and multivariate analyses revealed that NLR ≥2.04 was a risk factor the relapse of EOC within 5 years (P＜0.05).Conclusion:An elevated preoperative NLR value was correlated with EOC and multiple clinical indicators,which is an important independent relapse predictor for patients with EOC.