| 米诺环素对急性视神经炎大鼠视网膜神经节细胞的保护作用 |
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| 引用本文： | 张静,李平华. 米诺环素对急性视神经炎大鼠视网膜神经节细胞的保护作用[J]. 国际眼科杂志, 2011, 11(1): 43-45. DOI: 10.3969/j.issn.1672-5123.2011.01.015 |
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| 作者姓名： | 张静 李平华 |
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| 作者单位： | 1. 川北医学院附属医院眼科,中国四川省南充市,637000
2. 重庆医科大学附属第一医院眼科,中国重庆市,400016 |
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| 摘 要： | 目的:探讨米诺环素对大鼠视神经炎视网膜神经节细胞(RGCs)的影响,并与甲基强的松龙比较。方法:选取22只雌性Wistar大鼠随机分为正常对照组和实验组,实验组又分为实验对照组(EAE组)、米诺环素组、甲基强的松龙组(MP组)。HE染色观察视神经病理改变,TUNEL法检测RGCs凋亡率。结果:EAE组视神经纤维空泡样变性,轴突不规则肿胀,大量炎性细胞浸润,轴突内空泡样变性,髓鞘松解脱落,微丝微管消失,EAE大鼠视神经病理变化符合脱髓鞘性视神经炎改变。正常大鼠几乎未见RGCs凋亡,EAE组、米诺环素组、MP组较正常组相比,差异均有显著统计学意义(P<0.01),EAE组、MP组较米诺环素组相比,差异均有统计学意义(P<0.05),MP组与EAE组间的差异有统计学意义(P<0.05)。结论:采用豚鼠脊髓匀浆诱导建立大鼠EAE模型,其视神经病理学改变符合脱髓鞘性视神经炎的表现。米诺环素可抑制脱髓鞘性视神经炎RGCs凋亡,而甲基强的松龙对脱髓鞘性视神经炎RGCs无直接保护作用。
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| 关 键 词： | 视神经炎 视网膜神经节细胞 米诺环素 甲基强的松龙 |
Effects of minocycline on retinal ganglion cell of experimental optic neuritis in rats |
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| Jing Zhang and Ping-Hua Li. Effects of minocycline on retinal ganglion cell of experimental optic neuritis in rats[J]. International Eye Science, 2011, 11(1): 43-45. DOI: 10.3969/j.issn.1672-5123.2011.01.015 |
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| Authors: | Jing Zhang and Ping-Hua Li |
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| Affiliation: | Jing Zhang1,Ping-Hua Li2 1Department of Ophthalmology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan Province,China,2Department of Ophthalmology,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016 |
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| Abstract: | AIM:To investigate the effect of minocycline on retinal ganglion cells(RGCs)of experimental optic neuritis in Wistar rats.METHODS:Twenty-two female experimental Wistar rats were assigned to two groups randomly:normal control group and experimental group.Then the rats of experimental group were assigned to three groups randomly:experimental control group(EAE group),minocycline group,methylprednisolone group(MP group).We observed the pathological changes of optic nerve and retina,detected the apoptosis of RGC... |
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| Keywords: | optic neuritis retinal ganglion cells minocycline methylprednisolone |
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