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| BCG-PSN对荷瘤小鼠IL-2水平及肿瘤生长的影响 | |
| 引用本文： | 张杰玉,刘君炎,夏丰年,王慧. BCG-PSN对荷瘤小鼠IL-2水平及肿瘤生长的影响[J]. 武汉大学学报(医学版), 1997, 0(4) |
| 作者姓名： | 张杰玉 刘君炎 夏丰年 王慧 |
| 作者单位： | 湖南医科大学免疫学研究室 |
| 摘 要： | 将卡介菌多糖核酸（ＢＣＧ＿ＰＳＮ）及肿瘤坏死因子（ＴＮＦ＿α）用于荷肉瘤（Ｓ１８０）小鼠的治疗。结果证明，ＢＣＧ＿ＰＳＮ（０５ｍｇ／ｍｌ）及ＴＮＦ＿α（１０００Ｕ／ｍｌ）均能显著抑制Ｓ１８０实体瘤的生长，抑瘤率分别为５８１０％和３６２５％，抑瘤率与荷瘤鼠脾细胞的ＩＬ＿２诱生水平呈正的直线相关。ＢＣＧ＿ＰＳＮ还能显著延长荷Ｓ１８０腹水瘤鼠的存活期，生命延长率达３１５％。ＴＮＦ可能由于它的毒副作用而使其抑瘤效果低于ＢＣＧ＿ＰＳＮ，且与后者无协同作用。 |
| 关 键 词： | 卡介菌；多糖类；核糖核酸；肿瘤坏死因子；白细胞介素-2 |
Effect of BCG_PSN on Level of Interleukin 2 and Tumor Growth of Bearing S 180 Sarcoma Mice |
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| Zhang Jieyu,Liu Junyan,Xia Fengnian,et al. Effect of BCG_PSN on Level of Interleukin 2 and Tumor Growth of Bearing S 180 Sarcoma Mice[J]. Medical Journal of Wuhan University, 1997, 0(4) | |
| Authors: | Zhang Jieyu Liu Junyan Xia Fengnian et al |
| Abstract: | Polysaccharides nucleic acid fraction of BCG (BCG_PSN) and tumor necrosis factor alpha (TNF_α) were used to treat bearing S 180 sarcoma mice. It has been comfirmed that both BCG_PSN and TNF_α can inhibit the growth of S 180 solid sarcoma significantly, the inhibitory rates were 58.10% and 36.25% respectively. The level of interleukin 2 of splenocytes appeared to be in positive linear correlation with the inhibitory rates. BCG_PSN can also markedly prolong the living period of bearing S 180 ascites sarcoma mice. TNF had no sinergistic antitumor activity in combination with BCG_PSN and the efficiency of inhibiting tumor growth of TNF was lower than that of BCG_PSN due to its side_effect, whereas BCG_PSN did not appear to produce any side_effect in this study. |
| Keywords: | MeSH BCG strain polysaccharides RNA tumor necrosis factor IL_2 |
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