miR-34a靶向调控SOX7表达抑制垂体腺瘤细胞增殖 |
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引用本文: | 张笑天,张莉莉,孙苏安. miR-34a靶向调控SOX7表达抑制垂体腺瘤细胞增殖[J]. 南华大学学报(医学版), 2020, 0(6): 588-591, 603 |
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作者姓名: | 张笑天 张莉莉 孙苏安 |
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作者单位: | 南京医科大学附属淮安第一医院病理科,江苏 淮安 223300 |
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摘 要: | 探讨miR-34a通过靶向调控SOX7表达对垂体腺瘤细胞增殖的影响。结果显示,miR-34a mimics转染组和siRNA-SOX7组细胞活力、S期、G2期分别低于NC-miR-34a转染组和NC-SOX7转染组,细胞凋亡率和G1期分别高于NC-miR-34a转染组和NC-SOX7转染组。miR-34a mimics转染组SOX7 mRNA、SOX7蛋白的相对表达量低于NC-miR-34a转染组。结果表明,miR-34a可以通过靶向抑制SOX7表达抑制垂体腺瘤细胞增殖。
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关 键 词: | miR-34a SOX7 垂体腺瘤细胞 增殖 |
收稿时间: | 2019-08-15 |
修稿时间: | 2020-06-01 |
Inhibitory effect of miR-34a on the proliferation of pituitary adenoma cell by targeting SOX7 |
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Affiliation: | Department of Pathology,Huaian First Hospital Affiliated to Nanjing Medical University,Huaian 223300,Jiangsu,China |
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Abstract: | To investigate the effects of miR-34a on the proliferation of pituitary adenoma cell through the targeted regulation of SOX7 expression. The results showed that the cell vitality, S and G2 phases of the miR-34a mimics transfection group and siRNA-SOX7 transfection group were lower than those of the NC-miR-34a transfection group and the NC-SOX7 transfection group, respectively, and the apoptosis rate and G1 phase were higher than those of the NC-miR-34a transfection group and the NC-SOX7 transfection group, respectively. The relative expression levels of SOX7 mRNA and SOX7 protein in miR-34a mimics transfection group were lower than those in NC-miR-34a transfection group. The results indicated that miR-34a can inhibit the proliferation of pituitary adenoma cell by inhibiting SOX7 expression. |
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Keywords: | miR-34a SOX7 pituitary adenoma cell proliferation |
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