Effect of exercise on the expression of nerve growth factor in the spinal
cord of rats with induced osteoarthritis |
| |
| Authors: | Soo-Jin Park Min-Sik Yong Sang-Su Na |
| |
| Affiliation: | 1) Department of Rehabilitation Science, Graduate School, Daegu University, Republic of Korea;2) Department of Physical Therapy, Youngsan University, Republic of Korea;3) Department of Rehabilitation Science, Graduate School, Daegu University, Republic of Korea |
| |
| Abstract: | [Purpose] We examined the impact of exercise on the expression pattern of nerve growthfactor in the spinal cord of rats with induced osteoarthritis of the knee joint. [Subjectsand Methods] To produce monosodium iodoacetate-induced arthritis, rats were administered3 mg/50 µL monosodium iodoacetate through the interarticular space of the right knee. Theanimals were randomly divided into four groups: rats sacrificed 3 weeks after 0.9% salinesolution injection (shame group, n = 10), rats sacrificed 3 weeks after monosodiumiodoacetate injection (control group, n = 10), rats with 4 weeks rest from 3 weeks aftermonosodium iodoacetate injection (no exercise group, n = 10), and rats with 4 weekstreadmill training from 3 weeks after monosodium iodoacetate injection (exercise group, n= 10). Serial coronal sections of the lumbar spine were cut and processed forimmunohistochemistry. [Results] The expression of nerve growth factor was significantlyincreased in the EG compared with the SG, CG, and NEG. [Conclusion] Increased nerve growthfactor expression in the spinal cord due to exercise-induced stimulation can be effectivein treating chronic pain. Such treatment will contribute not only to improving the jointfunction of patients with chronic pain but also their quality of life.Key words: Osteoarthritis, Treadmill exercise, Nerve growth factor |
| |
| Keywords: | |
|
|
