EORTC QLQ-C30 and FACT-Lym for the assessment of health-related quality of life of newly diagnosed lymphoma patients undergoing chemotherapy |
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Affiliation: | 1. School of Nursing, Sun Yat-Sen University, Guangzhou, China;2. School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China;3. Sun Yat-Sen Memorial Hospital, Guangzhou, China;1. Clinical Trial Unit, Universidad de Navarra, Pamplona, Spain;2. Hematology Institute, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy;3. Lymphoma Tumour Group, BC Cancer Centre for Lymphoid Cancer and the University of British Columbia, Vancouver, BC, Canada;4. Department of Medical Oncology, Candiolo Cancer Institute, Fondazione del Piemonte per l''Oncologia, IRCCS, Candiolo, Italy;5. F. Hoffmann-La Roche Ltd, Basel, Switzerland;6. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA |
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Abstract: | PurposeThe aim of this study was to assess the validity of the European Organization for Research and Treatment of Cancer Quality of Life, Core 30 (EORTC QLQ-C30) and Functional Assessment of Chronic illness Therapy-Lymphoma (FACT-Lym) instruments (Greek version) in patients with lymphoma undergoing chemotherapy, as well as the comparative evaluation of the questionnaires themselves.MethodHealth related quality of life (HRQoL) was assessed using the two previously mentioned instruments as well as the generic Short Form 36 (SF-36), which was used as a standard and its scores were compared to the corresponding norms of the Greek general population. The sample consisted of 80 newly diagnosed patients with lymphoma, who had completed their chemotherapy treatment. Reliability (Cronbach's a), central tendency and variability for the scales were assessed. Associations between the instruments' scales were examined via Spearman's correlations.ResultsCronbach's a, was >0.70 for all the scales, with exception of the emotional well being scale of FACT-Lym and two functional scales of QLQ-C30. There is a significant correlation between similar scales of the questionnaires, and particularly strong (>0.50) between global, functional and physical subscales of the FACT-Lym and QLQ-C30 instruments. Also, five scales of the SF-36, showed significantly lower mean values compared to the corresponding Greek norms.ConclusionsThe Greek versions of FACT-Lym and QLQ-C30 appear to be reliable and valid tools for assessing HRQoL in this category of patients. The two disease-specific QoL instruments complement each other and neither can be replaced by the other. |
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Keywords: | Lymphoma Chemotherapy Health related quality of life (HRQoL) FACT-Lym QLQ-C30 SF-36 |
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