Outcome of BRCA1- compared with BRCA2-associated ovarian cancer: a nationwide study in the Netherlands |
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| Institution: | 1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam;2. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Groningen;3. Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center-Daniel den Hoed Cancer Center, Rotterdam;4. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen;5. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Medical Center St Radboud Nijmegen, Nijmegen;6. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Leiden University Medical Center, Leiden;7. Medical Director of the Netherlands Foundation for the Detection of Hereditary Tumours, Leiden;8. Department of Clinical Genetics, VU University Medical Center, Amsterdam;9. Division of Molecular Pathology, Division of Psychosocial Research and Epidemiology, NKI-AVL, Amsterdam;10. Department of Gynecologic Oncology, NKI-AVL, Amsterdam;11. Department of Gynecologic Oncology, Division of Woman and Baby, University Medical Center Utrecht, Utrecht;12. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Amsterdam Medical Center, Amsterdam;13. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands |
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| Abstract: | BackgroundRecent studies suggested an improved overall survival (OS) for BRCA2- versus BRCA1-associated epithelial ovarian cancer (EOC), whereas the impact of chemotherapy is not yet clear. In a nationwide cohort, we examined the results of primary treatment, progression-free survival (PFS), treatment-free interval (TFI), and OS of BRCA1 versus BRCA2 EOC patients.MethodsTwo hundred and forty-five BRCA1- and 99 BRCA2-associated EOC patients were identified through all Dutch university hospitals. Analyses were carried out with the Pearson's Chi-square test, Kaplan–Meier, and Cox regression methods.ResultsBRCA1 patients were younger at EOC diagnosis than BRCA2 patients (51 versus 55 years; P < 0.001), without differences regarding histology, tumor grade, and International Federation of Gynecology and Obstetrics (FIGO) stage. Complete response rates after primary treatment, including chemotherapy, did not differ between BRCA1 (86%) and BRCA2 patients (90%). BRCA1 versus BRCA2 patients had a shorter PFS (median 2.2 versus 3.9 years, respectively; P = 0.006), TFI (median 1.7 versus 2.8 years; P = 0.009), and OS (median 6.0 versus 9.7 years; P = 0.04). Differences could not be explained by age at diagnosis, FIGO stage or type of treatment.ConclusionsPFS and OS were substantially longer in BRCA2- than in BRCA1-associated EOC patients. While response rates after primary treatment were similarly high in both groups, TFI, as surrogate for chemosensitivity, was significantly longer in BRCA2 patients. |
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