Urinary levoglucosan levels in Austrian communities differing in agrarian quota |
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| Affiliation: | 1. Institute of Environmental Health, Center for Public Health, Medical University of Vienna, Austria;2. Medicine and Environmental Protection, Vienna, Austria;3. Environmental Agency Austria, Austria;1. State Environmental Protection Key Laboratory of Environment and Health (Taiyuan), Department of Radiological and Environmental medicine, China Institute for Radiation Protection (CIRP), Taiyuan 030001, Shanxi, China;2. Shanxi Provincial Key Laboratory of Environmental Hazards and Human Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, Shanxi, China;1. Universidad Simón Bolívar, Facultad de Ciencias Básicas y Biomédicas, Barranquilla, Colombia;2. Laboratório de Genética Toxicológica, Universidade Luterana do Brasil (ULBRA), Canoas, RS, Brazil;3. Departamento de Biofísica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil;4. Grupo de Investigación en Química y Biología, Universidad del Norte, Barranquilla, Colombia;1. Environmental Carcinogenesis Unit, IRCCS AUO San Martino IST-Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, 16132 Genoa, Italy;2. Department of Biomedical and Clinical Sciences, University of Milano, Luigi Sacco Hospital, via GB Grassi 74, 20157 Milano, Italy;3. International Centre for Pesticides and Health Risks Prevention (ICPS), Luigi Sacco Hospital, via GB Grassi 74, 20157 Milano, Italy;1. Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA;2. Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute for Environmental Health Sciences, Research Triangle Park, NC, USA;3. Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA;4. Division of Laboratory Sciences, National Center for Environmental Health, CDC, Atlanta, GA, USA;5. Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark;1. Laboratory for Cell Genetics, Faculty of Sciences and Bioengineering, Vrije Universiteit Brussel, Brussels, Belgium;2. Commonwealth and Scientific Industrial Research Organization, Genome Health and Personalised Nutrition Laboratory, Food and Nutrition Flagship, Adelaide, South Australia, 5000, Australia;3. Environmental Carcinogenesis Unit, Ospedale Policlinico San Martino, L.go Rosanna Benzi, 10 16132, Genova, Italy |
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| Abstract: | Levoglucosan is a sugar anhydride produced by combustion of carbohydrates. In ambient monitoring it serves as an indicator for wood smoke. Its use in human biomonitoring, however, is not yet widespread. This study investigated whether levoglucosan in urine is a suitable biomarker for regional differences in wood smoke exposure in the winter season.Within the first Austrian biomonitoring survey, pooled urine samples from mothers as well as children of five communities of different size (two-stage random stratified sampling) were analysed by HPLC. As an indicator of exposure to polycyclic aromatic hydrocarbons (PAH) that are also prevalent in wood smoke, 1-hydroxypyrene was determined.In each town levoglucosan was found in higher levels in the pooled children's samples than in the pooled mothers’ samples. It correlated well with the agrarian quota. 1-Hydroxypyrene concentrations were higher in areas with higher population density.Correlation of urinary levoglucosan concentrations with the agrarian quota may be explained by higher wood smoke exposure in communities with higher agrarian quota.To our knowledge this study is the first investigation on this issue in Europe. It indicates that human biomonitoring of levoglucosan may be suitable to detect differences in regional exposure to wood smoke. |
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