Neurological assessment in infants discharged from a neonatal intensive care unit |
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| Affiliation: | 1. Department of Physiotherapy, University of Melbourne, Parkville, Australia;2. Victorian Infant Brain Studies, Murdoch Children''s Research Institute, Parkville, Australia;3. Department of Physiotherapy and Newborn Services, The Royal Women''s Hospital, Parkville, Australia;4. Department of Paediatrics, University of Melbourne, Parkville, Australia;5. Department of Psychology and Counselling, La Trobe University, Bundoora, Australia;1. Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Kodakyar St, Daneshjo Blvd, Evin, P.O Box: 14155-6386, Tehran, Iran;2. Tehran University of Medical Science, Children''s Medical Center of Excellence, Dr Gharib St, Keshavarz Blvd, P.O Box: 14155-6386, Tehran, Iran;3. Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Koodakyar Street, Daneshjoo Ave, Evin, Tehran 1985713834, Iran;4. Department of Pediatrics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran;1. School of Medicine, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima 15102, Peru;2. Instituto Nacional Materno Perinatal, Jr Santa Rosa 941, Cercado de Lima, Lima 15001, Peru;3. Hospital Nacional Cayetano Heredia, Av Honorio Delgado 262, San Martin de Porres, Lima 15102, Peru;4. School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima 15102, Peru;5. Hospital Nacional Madre Niño San Bartolome, Av Alfonso Ugarte 825, Lima 15001, Peru;6. Hospital Nacional Guillermo Almenara, Av. Miguel Grau 800, La Victoria 15033, Lima, Peru;7. Hospital Nacional Alberto Sabogal Sologuren, Jr. Colina 1081, Bellavista 07011, Callao, Peru;9. Center for Infectious Diseases, University of Texas Health Science Center at Houston, Houston, TX, United States |
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| Abstract: | BackgroundLongitudinal motor assessment in infants at different neurodevelopmental risk has not been previously evaluated using structured assessments.AimTo verify if the Hammersmith Infant Neurological Examination (HINE) is a good tool to predict the neuromotor outcome in infants discharged from a level II–III Neonatal Intensive Care Unit (NICU)MethodsIn this cohort analysis, 1541 infants discharged from our NICU between January of 2002 and the April 2006 were enrolled and assessed using the HINE at 3, 6, 9, 12 months. At two years, these infants were further assessed, and grouped into infants with normal outcome (1150), with mild disability (321) and with cerebral palsy (70),ResultsCorrelation analysis of Spearman showed a significant (p < 0.0001) and moderate (r2 = −0.55 to −0.73) negative correlation between HINE scores (3, 6, 9, 12 months) and neurological outcome at two years. Cut-off scores for each assessment' age were provided as predictive value for cerebral palsy.DiscussionThis study mainly showed that HINE, as soon as the first months of life, helps in the process of prediction of neurological outcome at two years of age in a heterogeneous population of infants discharged from an NICU. |
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