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1-N-Alkyl analogs of butirosin. |
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| Authors: | T Hayashi H Saeki N Takeda E Ohko |
| Abstract: | Butirosin (Ia), 5'-amino-5'-deoxy-(Ic), 3',4'-dideoxy-(Ie), and 5'-amino-3',4',5'-trideoxy-butirosin A (If) were converted into the corresponding 1'-deoxo derivatives, Ib, Id, Ig, and Ih by borane reduction. In addition, xylostasin (IIIa) was converted into its 1-N-ethyl derivative (IIIb) by reductive ethylation. Their antibacterial activities were discussed. |
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