Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801 |
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Authors: | Fumagalli Fabio Molteni Raffaella Bedogni Francesco Gennarelli Massimo Perez Jorge Racagni Giorgio Riva Marco A |
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Institution: | Center of Neuropharmacology and Center of Excellence for Neurodegenerative Diseases (CEND), Department of Pharmacological Sciences University of Milan, Via Balzaretti 9, 20133 Milan, Italy. Fabio.Fumagalli@unimi.it |
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Abstract: | Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed. |
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