| 肝癌的表观遗传学特征及其临床意义 |
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| 引用本文： | 巩艳,杨云生,郭明洲. 肝癌的表观遗传学特征及其临床意义[J]. 胃肠病学和肝病学杂志, 2010, 19(4) |
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| 作者姓名： | 巩艳 杨云生 郭明洲 |
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| 作者单位： | 中国人民解放军总医院消化科,北京,100853 |
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| 基金项目： | 本课题受973课题资助，博士后基金资助 |
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| 摘 要： | 表观遗传学是研究基因表达的学科,其改变不依赖于基因序列的改变,研究内容包括DNA甲基化、组蛋白修饰和非编码RNA。与基因突变不同,表观遗传学的改变在一定条件下可以逆转,这一特性为疾病的治疗提供了新的机会。肝癌是威胁人类健康的恶性肿瘤之一,发病机制不清。肝癌表观遗传学研究越来越受到人们的重视,本文将对肝癌的表观遗传学改变进行阐述。
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| 关 键 词： | 肝癌 DNA甲基化 组蛋白修饰 非编码RNA |
Epigenetics character and clinical value in human hepatic cancer |
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| GONG Yan,YANG Yunsheng,GUO Mingzhou. Epigenetics character and clinical value in human hepatic cancer[J]. Chinese Journal of Gastroenterology and Hepatology, 2010, 19(4) |
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| Authors: | GONG Yan YANG Yunsheng GUO Mingzhou |
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| Affiliation: | GONG Yan,YANG Yunsheng,GUO Mingzhou Department of Gastroenterology , Hepatology,PLA General Hospital,Beijing 100853,China |
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| Abstract: | Epigenetics studies on gene expression but don't rely on DNA sequence.Epigenetics changes include DNA methylation,histone modification and non-coding RNA.Different from mutations,the epigenetics change is reversible.This character makes it possible for treatment disease by epigenetics related approach.Hepatic cancer is one of the most malignant diseases.More and more researchers are interested in epigenetics changes in human hepatic cancer.This review is mainly focused on epigenetic changes in hepatic cance... |
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| Keywords: | Hepatic cancer DNA methylation Histone modification Non-coding RNA |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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