前列腺素E1联合弥可保治疗糖尿病周围神经病变的疗效

目的探讨前列腺素E1联合弥可保治疗糖尿病周围神经病变(DPN)的临床疗效。方法 2008年2月至2011年12月在我院内分泌科住院治疗的108例DPN患者随机分为2组,对照组50例采用常规治疗和弥可保治疗,实验组58例在对照组的基础上应用前列腺素E1。比较两组的临床疗效及治疗前后神经传导速度。结果实验组的临床总有效率为89.65%,明显高于对照组的72%(P<0.05)。治疗后,对照组正中神经和腓总神经的MNCV和SNCV传导速度明显提高(P<0.05);实验组的正中神经和腓总神经的MNCV和SNCV传导速度明显高于治疗前及对照组(P<0.01)。结论前列腺素E1联合弥可保治疗DPN,能有效改善神经传导速度,临床有效率高,值得在临床上推广应用。

Therapeutic effect of PGE-1 combined with mecobalamin treatment for 58 patients with diabetic peripheral neuropathy

Objective To study the clinical therapeutic effect of PGE-1 combined with mecobalamin on diabetic peripheral neuropathy.Methods 108 patients with diabetic peripheral neuropathy in our department from February 2008 to December 2011 were divided into two groups randomly.In addition to control blood glucose,50 cases were treated with mecobalamin(control group),58 cases were treated with PGE-1 combined with mecobalamin on the basis of the treatment of control group(treatment group).The clinical effect and nerve conduction velocity of the two groups were compared.Results After treatment,the total effective rate of treatment group(89.65%)was significantly higher than that of control group(72%,P<0.05);The motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and peroneal nerve in treatment group were significantly higher than those in control group(P<0.01).Conclusion PGE-1 combined with mecobalamin can be used to improve the nerve conduction velocity and clinical efficiency,it is worthy of clinical application.