前瞻性观察甲状腺结节的SonoVue超声造影增强模式

目的 探讨甲状腺结节实时灰阶超声造影(CEUS)的增强模式及其对甲状腺结节的鉴别诊断价值.方法 对常规超声检测出的95例患者104个甲状腺结节行CEUS检查,其中良性病灶53个,恶性病灶51个;囊性结节1个,囊实性结节41个,实性结节62个.采用低机械指数灰阶脉冲反相谐波成像,静脉团注SonoVue 1.2 ml,观察时间≥3 min(MI 0.05～0.08).观察甲状腺良恶性结节的灰阶内部回声结构和CEUS增强模式.结果 注入造影剂后,甲状腺结节呈现均匀增强、不均匀增强、环状增强和无增强4种表现.甲状腺良恶性结节的增强模式总体上有差别(P<0.01).环状增强提示良性可能性大,敏感度83.02%,特异度94.12%,阳性预测值93.62%,阴性预测值84.21%,准确率88.46%.不均匀增强提示恶性可能大,敏感度88.24%,特异度92.45%,阳性预测值91.84%,阴性预测值89.09%,准确率90.38%.1个囊性结节为良性结节,表现为环状增强.对于囊实性结节和实性结节,环状增强诊断良性结节的阳性预测值分别为93.10%和94.12%,不均匀增强诊断恶性结节的阳性预测值分别为88.89%和92.50%.结论 CEUS在甲状腺结节良恶性鉴别诊断中具有重要应用价值.

Prospective observation of contrast-enhanced patterns of thyroid nodules with SonoVue

Objective To characterize the enhancement-patterns of thyroid nodules on gray-scale real time contrast-enhanced ultrasound (CEUS),and to evaluate the potential value of CEUS for the differential diagnosis of thyroid nodules. Methods One hundred and four thyroid nodules in 95 patients detected with B-mode ultrasonography (51 malignant and 53 benign) were examined with CEUS prospectively. One cystic nodule,41 mixed nodules and 62 solid nodules were included. After intravenous bolus injection of 1.2 ml of Sono...