VEGF、EGFR、p16在唇癌与口腔鳞癌中的表达及临床意义

目的 检测血管内皮生长因子（vascular endothelial factor,VEGF)、表皮生长因子受体（epidermal growth for receptor,ERFR)及p16在唇癌及口腔鳞癌组织中的表达分布特征，探讨其在癌发生发展中的作用及临床病理意义，为唇癌及口腔鳞癌的抗血管生成治疗提供临床病理学依据。方法 应用免疫组化LSAB法检测69例唇癌及口腔鳞癌组织中VEGF、EGFR，p16蛋白的表达及变化。结果 唇癌及口腔鳞癌VEGF、EGFR,p16蛋白表达率分别为71．01％、46．37％及28．98％。不同部位唇癌及口腔鳞癌组织间VEGF、GEFR、p16阳性表达率差异无显著性（P＞0．05）；VEGF在唇癌及口腔鳞癌与非瘤组织中的阳性表达率分别为71．01％、10．00％，二者差异有显著性（P＜0．05）；VEGF、EGFR、p16在唇癌及口腔癌组织中的阳性表达无明显相关（P＞0．05）。结论 唇癌及口腔鳞癌组织中VEGF、EGFRp16之间蛋白表达无相关；VEGF在非瘤组织与唇癌及口腔鳞癌中的表达率差异有显著性；VEGF在唇癌及口腔鳞癌发生发展中起重要作用，可作为有用的标志物。

Expression of VEGF、EGFR、p16 in lip cancers and oral squamous cell carcinomas and their clinic significance

OBJECTIVE: To detect the expression of vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), p16 protein in lip cancers and oral squamous cell carcinoma (OSCC) as well as their clinicopathological significance. METHODS: Immunohistochemisty for expression VEGF, EGFR, P16 were carried out in 69 cases of lip cancers and OSCC. RESULTS: Expression of VEGF, EGFR, p16 protein in OSCC and lip cancers was respectively 71.01%, 46.37%, 28.98% and there were no significance between their positive expressions (P > 0.05) as well as in different sites of them (P > 0.05). Expression of VEGF was respectively 71.01% in cancers and 10.00% in non-tumor tissues, there was statistic significance among those (P < 0.05). CONCLUSIONS: The results show that there is no correlation to the expression of VEGF, EGFR and P16 protein in OSCC and lip cancers. It is suggests that the expression of VEGF might become one of the useful markers for OSCC.