基于CiteSpace和VOSviewer可视化分析药食同源中药罗汉果的发展态势

目的 罗汉果Siraitia grosvenorii为药食同源中药，具有较高营养价值、药用价值。随着居民饮食消费观念改变，天然甜味剂市场需求增加，而罗汉果作为天然代糖，热度日趋增强。分析罗汉果的研究现状和发展态势，为未来研究拓展提供参考。方法 以罗汉果为关键词，从中国知网（CNKI）数据库与Web of Science（WOS）数据库核心集检索并导出相关文献，并导入Endnote软件进行查重、筛选和格式转换后导出题录。最后使用CiteSpace、VOSviewer、Excel软件分别对罗汉果中英文文献的整体产出、研究主体及合作网络、高被引文献、关键词等进行分析。结果 共纳入文献551篇，其中中文文献458篇，英文文献93篇。罗汉果的年发文量大体呈现增长趋势，共有14个国家参与罗汉果的研究，其中以中国为主。中英文文献居发文量榜首的机构分别为广西壮族自治区药用植物园、Chinese Academy of Sciences（中国科学院）。中英文文献发文量最多的作者均为马小军。研究领域内各机构和团队之间的交流合作有待加强。被引频次前10的中英文文献主要研究方向为罗汉果的化学成分、植物培养及药理作用研究等。罗汉果苷V作为罗汉果中备受关注的活性物质是该领域的研究热点。中英文关键词共现、聚类显示研究热点集中于罗汉果的栽培、提取分离、工艺优化、药理作用、应用等方面。结论 罗汉果研究目前仍处于上升阶段，未来罗汉果领域的研究重点应关注罗汉果苷V的高含量品种选育、提取工艺等方面，另罗汉果多糖结构与活性的关联性也是罗汉果发展的重要趋势。

Visual analysis on development trend of medicine and food homologous traditional Chinese medicine Siraitia grosvenorii based on CiteSpace and VOSviewer

Objective Luohanguo (Siraitia grosvenorii) is a traditional Chinese medicine with the exact origin as medicine and food. It has high nutritional value and medicinal value. The demand for natural sweeteners has increased with the changes in dietary consumption concept of residents, while S. grosvenorii as a raw sugar substitute has been welcomed either. The research status and development trend of the field of S. grosuenorii are analyzed to provide a reference for the development strategy of future research. Methods In this study, the publications with the keyword of S. grosuenorii were retrieved and extracted from the CNKI database and Web of Science database, respectively. The data were imported into Endnote software for re-checking, screening, and formatting conversion. Finally, CiteSpace, VOSviewer, and Excel software were used to analyze the number of the overall output profile, research subjects, collaboration network, highly cited papers, and keywords. Results A total of 551 publications were consisted, including 458 in Chinese and 93 in English. The annual number of publications of S. grosuenorii showed an increasing trend. China was the main country to study about S. grosuenorii, while 14 countries in total. Guangxi Botanical Garden of Medicinal Plants and Chinese Academy of Sciences were ranked at the top regarding the number of publications in domestic and overseas. The author with the most published articles in Chinese and English was Xiaojun Ma. In general, the institutions and research teams in the field is expected to strengthened the exchanges and cooperation. The top 10 most cited Chinese and English literature mainly focused on the chemical composition, plant culture, and pharmacological action of S. grosuenorii. As the most concerned active substance in S. grosuenorii, mogroside V is a continuous research hotspot in S. grosuenorii. The co-occurrence of Chinese and English keywords and cluster analysis showed that the research focused on the cultivation, extraction and separation, process optimization, pharmacological effect, and application of S. grosuenorii. Conclusion The research field of S. grosuenorii is in the stage of development. In the future, more attention should be paid to the breeding of high-content mogroside V varieties and the extraction technology. In addition, the correlation between the structure and activity of S. grosuenorii polysaccharides is also an essential trend in the development of S. grosuenorii.