Influenza and pneumococcal vaccination as a model to assess C-reactive protein response to mild inflammation |
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| Institution: | 1. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands;2. Department of Clinical Chemistry, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands;3. Department of Clinical Epidemiology, University Medical Center Leiden, P.O. Box 9600, 2300 RC, Leiden, The Netherlands;1. Division of Infectious Diseases, University of Pennsylvania, Philadelphia, Pennsylvania;2. Child Health Evaluation and Research Unit, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan;3. Michigan Department of Community Health, Lansing, Michigan;4. Children''s Outcomes Research Program, University of Colorado Denver, Aurora, Colorado;1. Department of Epidemiology, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, IA 52242, United States;2. Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, United States;3. Department of Public Health Sciences, University of California at Davis, Med Sci 1C, Davis, CA, United States;4. Department of Preventive Medicine, University of Tennessee Health Science Center, 600 Jefferson Avenue, Memphis, TN 38105, United States;5. Medstar Health Research Institute and Georgetown/Howard Universities Center for Clinical and Translational Research, 6525 Belcrest Road #700, Hyattsville, MD, United States;6. Department of Epidemiology, University of California, Box 951740, 27-138 CHS, Los Angeles, CA 90095, United States;7. Kaiser Permanente Center for Health Research, 3800 N Interstate Avenue, Portland, OR 97227, United States;8. Department of Family, Community and Rural Health, The Commonwealth Medical College, Medical Sciences Building, Room 1013, 525 Pine Street, Scranton, PA 18509, United States;9. John A. Burns School of Medicine and Cardiovascular Division, University of Hawaii, The Queens Medical Center, 1301 Punchbowl Street, Honolulu, HI 96813, United States;10. Department of Internal Medicine, University of Iowa, 145 North Riverside Drive, S400 CPHB, Iowa City, United States;1. Teaching and Research Office of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China;2. School of Public Health, Nantong University, Nantong, China;3. Department of AIDS and STD, Shanghai Municipal Center for Disease Control and Prevention, Shanghai Municipal Institutes for Preventive Medicine, Shanghai, China;4. Department of Oncology, Medical School of Southeast University, Nanjing, China;5. Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, China;6. Department of Pathology, New York University School of Medicine, New York, NY, USA;7. Department of Infectious Disease Prevention and School Health, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China;8. Hospital Office, Southeast University Hospital, Nanjing, China;1. Onco-Hematology, Centre Léon Bérard, UMR CNRS 5239, Université Lyon 1, Lyon, France;2. Health Sciences Research, Mayo Clinic, Rochester, MN, USA;3. Department of Hematology, CHU Dijon, Dijon, France;4. Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA;5. Department of Hematology, Warsaw, Poland;6. UMR CNRS 5239, Université Lyon 1, Lyon, France;7. Department of Hematology, APHP, Hôpital Saint Louis, Paris, France;8. Department of Hematology, CHU de Besançon, France;9. Department of Hematology, CHU, Lille, France;10. Unité Hémopathies lymphoïdes, Hôpital Henri Mondor, Créteil, France;11. University of Iowa, Holden Comprehensive Cancer Center, Iowa City, IA, USA;12. Department of Hematology, Centre Henri Becquerel, Rouen, France;13. Department of Hematology, Institut Gustave Roussy, Villejuif, France;14. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA;15. Department of Pathology, APHP, Hôtel Dieu, Paris, France;p. Department of Hematology, UMR CNRS 5239, Université Lyon 1, HCL, Pierre-Bénite, France |
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| Abstract: | This study was set up to examine whether an influenza vaccine or an influenza vaccine in combination with pneumococcal vaccine can be used as a model to study responses to mild stimulation of the inflammatory system.In this study, 19 subjects received the influenza vaccine, 20 subjects the combination of influenza and pneumococcal vaccine. CRP and prothrombin fragment 1 and 2 (F1 + 2) were measured at baseline, and two times after vaccination. Influenza vaccination increased CRP by 0.20 mg/L, and influenza in combination with pneumococcal vaccine increased CRP by 0.60 mg/L. F1 + 2 increased 0.15 nmol/L after the combined vaccination; an increase in response to the influenza vaccination was not statistically significant.Our findings show that the influenza vaccine alone as well as the combination of the influenza and pneumococcal vaccine increases CRP-levels with a peak 2 days after vaccination. |
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