Does influenza vaccination exacerbate asthma in children? |
| |
| Affiliation: | 1. Clinical Laboratory Center, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Tochigi, 321-0293 Japan;2. Clinical Research Center, National Hospital Organization Kinki-chuo Chest Medical Center, 1180 Nagasone-cho, Kita-ku, Sakai, Osaka, 591-8555 Japan;3. Department of Infection Control and Clinical Laboratory of Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293 Japan;4. Division of Infection Control, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Tochigi, 321-0293 Japan;1. Department of Pediatrics, Golisano Children''s Hospital, The University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA;2. Division of Nutritional Sciences, Cornell University, 230 Savage Hall, Ithaca, NY, 14850, USA;1. Ishikawa Nanbu Livestock Hygiene Service Center, Saida, Kanazawa, Ishikawa 920–3101, Japan;2. Research and Education Center for Prevention of Global Infectious Disease of Animal, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan;3. Joint Faculty of Veterinary Medicine, Kagoshima University, Korimoto, Kagoshima 890-0065, Japan;4. Tochigi Prefectural Central District Animal Hygiene Service Center, Hiraidekougyoudanchi, Utsunomiya, Tochigi 321-0905, Japan;5. Kurayoshi Livestock Hygiene Service Center, Kiyotani, Kurayoshi, Tottori 683-0017, Japan;6. Department of Virology II, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan;7. Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan;8. Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo 180-8602, Japan;9. Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan |
| |
| Abstract: | Background:The risks of influenza vaccination in asthmatic children are still being discussed. Especially, the risk that influenza vaccination may exacerbate asthma is an issue in this debate.Methods:We conducted a randomised double-blind placebo-controlled trial in 696 children 6–18 years of age with asthma recruited in general practice during two influenza seasons, 1999–2000 and 2000–2001. Children participated for only one season. During the first week after vaccination, participants recorded local, influenza like and asthma symptoms as well as use of medication, health care use and absenteeism.Results:Except for cough during the day in the first season, favouring placebo, there were no differences indicating that vaccination exacerbates asthma.Conclusions:Influenza vaccination does not seem to exacerbate asthma. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
