| 烫伤后大鼠肝脏药物代谢酶和脂质过氧化活性的变化以及水飞蓟宾的作用 |
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| 引用本文： | 谢京儿,廖锡麟. 烫伤后大鼠肝脏药物代谢酶和脂质过氧化活性的变化以及水飞蓟宾的作用[J]. 第二军医大学学报, 1989, 0(5) |
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| 作者姓名： | 谢京儿 廖锡麟 |
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| 作者单位： | 第二军医大学训练部药理学教研室(谢京儿)，第二军医大学训练部药理学教研室(廖锡麟) |
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| 摘 要： | 用Sprague-Dawley大鼠制成体表面积10％～15％深Ⅱ度烫伤,观察肝脏药物代谢酶和脂质过氧化活性的变化,并观察维生素E、水飞蓟宾对上述变化的影响。实验结果发现烫伤后肝微粒体细胞色素P-450含量及活性明显降低,同时伴有肝脂质过氧化活性增高。维生素E和水飞蓟宾能抑制烫伤后肝脂质过氧化活性的增高,并对肝脏药物代谢酶活性有保护作用。
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| 关 键 词： | 肝微粒体 药物代谢酶系统 脂质过氧化 烫伤 水飞蓟宾 |
CHANGES OF LIVER MICROSOMAL DRUG-METABOLIZING SYSTEM AND LIPOPEROXIDATION ACTIVITY IN SCALDED RATS AND THE EFFECTS OF SILYBIN |
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| Xie Jiner,et al. CHANGES OF LIVER MICROSOMAL DRUG-METABOLIZING SYSTEM AND LIPOPEROXIDATION ACTIVITY IN SCALDED RATS AND THE EFFECTS OF SILYBIN[J]. Former Academic Journal of Second Military Medical University, 1989, 0(5) |
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| Authors: | Xie Jiner et al |
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| Affiliation: | Department of Pharmacology |
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| Abstract: | The dynamic changes of liver microsomal drug-metabolizing system ( MDMS) and lipoperoxidation were studied in scalded rats.The effects of treatment with vitamin E and silybin were also evaluated.The results showed that liver microsomal cytochrome P-450 content, and p-nitroanisole demethylase (p-NOD) and aniline hydroxylase (AH) activity decreased markedly postburn.On the contrary, liver lipoperoxide and microsomal lipoperoxidation increased significantly after scalding.Both the increase of liver lipoperoxide and microsomal lipoperoxidation and the decrease of MDMS activity were prevented by vitamin E and silybin treatments. |
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| Keywords: | liver rnicrosorne drug metabolizing system lipoperoxidation scalding rats |
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