发生于耳鼻咽喉部的原发性神经内分泌癌4例

目的：探讨发生于耳鼻咽喉部的原发性神经内分泌癌的的病理、临床特性及治疗方法；方法：喉非典型类癌1例，行会厌切除术；鼻咽部非典型类癌1例。行放疗；中耳类癌1例，行右中耳探查及乳突根治术；右鼻腔小细胞神经内分泌癌1例，行鼻右侧切开肿瘤切除术及放疗。结果：喉非典型类癌及鼻咽部非典型类癌患者分别于5年和1年后死亡；中耳类癌患者随访3年右耳术腔干洁；右鼻腔小细胞神经内分泌癌随访2年未见复发。结论：发生于耳鼻咽喉部的原发性神经内分泌癌可分为类癌、非典型类癌、小细胞神经内分泌癌。类癌为低度恶性。小细胞神经内分泌癌为高度恶性，非典型类癌介于二者之间。治疗以手术切除为主．

Four cases of primary neuroendocrine carcinoma in ear,nose, pharynx and larynx

Objective:To discuss the clinical pathologic features and therapeutic method of the primary neuroendocrine carcinoma in ear, nose, pharynx, larynx.Method:One case of atypical carcinoid tumor in larynx is treated by epiglottidectomy.One case of atypical carcinoid tumor in rhinopharynx is treated by radiotherapy. One case of typical carcinoid tumor in middle ear is treated by exploratory incision and radical mastoidectomy. One case of small cell neuroendocrine carcinoma in right nasal cavity is treated by resection and radiotherapy.Result:The patient of atypical carcinoid tumor in larynx died after 5 years and the patient of atypical carcinoid tumor in rhinopharynx died after 1 year.The patient of typical carcinoid tumor in middle ear was followed-up 3 years and the patient of small cell neuroendocrine carcinoma in right nasal cavity was followed-up 2 years,and the carcinomas didn't recrudesce.Conclusion:The primary neuroendocrine carcinoma in ear, nose, pharynx, larynx is classified in three states: typical carcinoid tumor, atypical carcinoid tumor and small cell neuroendocrine carcinoma. Typical carcinoid tumor is a kind of low malignant tumor and small cell neuroendocrine carcinoma is a kind of high malignant tumor and atypical carcinoid tumor is a kind of medium malignant tumor.The chief therapeutic method of the primary neuroendocrine carcinoma in ear, nose, pharynx, larynx is surgical intervention .