西酞普兰合并丁螺环酮治疗卒中后抑郁的疗效与安全性

目的：探讨西酞普兰合并丁螺环酮治疗卒中后抑郁的疗效与安全性。方法：脑卒中后抑郁患者60例随机分为观察组和对照组各30例,均服用西酞普兰20mg/d,2周内增至30-40mg/d;观察组同时加用丁螺环酮30mg/d。结果：与治疗前比较,治疗1周时,汉密顿抑郁量表（HAMD）评分,观察组即明显下降（P〈0.05）,治疗2周时对照组开始下降。治疗8周时,2组HAMD和中国卒中量表（CSS）评分均显著下降,日常生活活动能力量表（ADL）明显提高（P〈0.05或0.01）;与对照组比较,观察组HAMD、ADL改善更明显（P〈0.05）,副反应量表（TESS）则无差异。治愈显效率观察组优于对照组（83.3%、60%,P〈0.05）。结论：西酞普兰合并丁螺环酮能加强卒中后抑郁的治疗作用,且起效迅速,患者症状改善明显,显示出联合用药的优点。

Efficacy and Safety of Citalopram Combined with Buspirone in Treatment of Patients with Post-stroke Depression

Objective:To explore efficacy and safety of citalopram combined with buspirone in treatment of patients with post-stroke depression.Methods:Sixty patients with post-stroke depression were randomly assigned to study group(treated with citalopram combined with buspirone)and control group(treated with citalopram alone)for 8 weeks(each group having 30 cases).Hamilton Depressive Scale(HAMD),Chinese Stroke Scale(CSS),Activity of Daily Living Scale(ADL)and Treatment Emergent Side effect Scale(TESS)were used to evaluate the efficacy and adverse effect respectively.Results:After 8 weeks,the apparent effective ratio and the scores of ADL in study group were significantly higher than those in control group.The scores of HAMD in study group were lower significantly than those in control group after 4 weeks.CSS and ADL were markedly improved in two groups after treatment.The incidence of adverse effect and the scores of TESS and CSS had no significant difference between the two groups.Conclusion:Citalopram combined with buspirone is more effective than citalopram alone in treatment of post-stroke depression.It is the same safe as the latter.