高血压患者血压变异性与肱踝脉搏波传导速度的关系研究

目的探讨高血压患者血压变异性与肱踝脉搏波传导速度(brachial-ankle pulse wave velocity,baP-WV)的关系。方法选择原发性高血压患者313例,根据baPWV值,将其分为两组:baPWV正常组(baPWV<1 400cm/s)87例,baPWV升高组(baPWV≥1 400 cm/s)226例。比较两组患者年龄、性别构成比、血糖、血脂、血肌酐、血尿酸、血压及血压变异性。结果单因素分析显示,baPWV升高组患者的年龄、胆固醇、低密度脂蛋白、高密度脂蛋白、24 h平均收缩压、24 h收缩压变异性及24 h舒张压变异性均高于baPWV正常组(P<0.05),代入Logistic回归分析显示年龄、胆固醇、高密度脂蛋白、24 h平均收缩压、24 h收缩压变异性及24 h舒张压变异性与baPWV呈相关性(P<0.05)。结论高血压患者24 h收缩压变异性和舒张压变异性是影响baPWV的独立因素。

Relationship between Blood Pressure Variability and Brachial-ankle Pulse Wave Velocity in Hypertensive Patients

Objective To explore the relationship between blood pressure variability and brachial-ankle pulse wave velocity(baPWV) in hypertensive patients.Methods Totally 313 patients with essential hypertension were enrolled in this study and divided into normal baPWV group(baPWV<1 400cm/s,n=87)and high baPWV group(baPWV≥1 400cm/s,n=226)based on their baPWV values.Age,gender ratio,fasting blood glucose(FBG),blood lipids including cholesterol(CHO),low-density lipoprotein cholesterol(LDL),and high-density lipoprotein cholesterol(HDL),serum creatinine(Cr),blood uric acid(UA),blood pressure,and blood pressure variability were measured.Results Univariate analysis revealed that age,CHO,LDL,HDL,24-hour systolic blood pressure,24-hour systolic blood pressure variability,and 24-hour diastolic blood pressure variability were significantly higher in high baPWV group than in normal baPWV group(P<0.05).Multivariate Logistic regression analysis indicated that age,CHO,HDL,24-hour systolic blood pressure,24-hour systolic blood pressure variability,and 24-hour diastolic blood pressure variability were independent influencing factors for baPWV(P<0.05).Conclusion In hypertensive patients,24-hour systolic blood pressure variability and 24-hour diastolic blood pressure variability are independent influencing factors for baPWV.