The herpes-specific immune response of individuals with herpes-associated erythema multiforme compared with that of individuals with recurrent herpes labialis |
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Authors: | S. L. Brice S. S. Stockert J. D. Bunker D. Bloomfield J. C. Huff D. A. Norris W. L. Weston |
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Affiliation: | (1) Department of Dermatology, University of Colorado School of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, 80262 Denver, CO, USA |
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Abstract: | Infection with herpes simplex virus (HSV) is the most common precipitating factor in the development of erythema multiforme (EM). It is not known why only a few of the many individuals who experience recurrent HSV infection also develop herpes-associated EM (HAEM), although a difference in the HSV-specific immune response has been postulated. The purpose of this study was to compare the HSV-specific immune response of individuals with HSV infection alone with that of individuals with HAEM. There were 21 patients in each of the two groups. Four parameters of the HSV-specific immune response were examined: (1) anti-HSV IgG titers were measured by ELISA; (2) antibody neutralization was assessed using a plaque assay; and (3) antibody-dependent complement-mediated cytotoxicity, and (4) antibody-dependent cellular cytotoxicity were investigated using a previously described in vitro HSV-specific cytotoxicity assay. No statistically significant differences were detected between the two patient groups. Thus, a difference in these HSV-specific immune mechanisms does not explain the development of HAEM in some individuals with recurrent HSV infection.Grant support: AI 16637 from the National Institutes of Allergy and Infectious Disease |
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Keywords: | Herpesvirus hominis Cytotoxicity tests Humoral immunity |
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