| 硒对衰老小鼠脑神经细胞及线粒体的保护作用 |
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| 引用本文： | 高良才,陈婉蓉,傅中滇,阮素云. 硒对衰老小鼠脑神经细胞及线粒体的保护作用[J]. 中国公共卫生, 2002, 18(7): 769-770 |
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| 作者姓名： | 高良才 陈婉蓉 傅中滇 阮素云 |
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| 作者单位： | 1. 华东师范大学生命科学学院,上海,200062
2. 上海市预防医学研究所 |
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| 基金项目： | 国家自然科学基金资助项目 (No .39670 637) |
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| 摘 要： | 目的 探讨硒对老化神经元及线粒体的作用机理。方法 采用D -半乳糖致小鼠衰老模型 ,观察硒对衰老小鼠脑细胞的SOD、MDA、GSH -Px、GSH、MAO -B、脂褐素以及线粒体形态结构的影响。结果 硒可以明显提高D -半乳糖衰老小鼠脑细胞SOD、GSH -Px的酶活性 ,增加GSH含量 ,减少脂褐素和MDA的含量 ,抑制MAO -B的酶活性 ,保护脑线粒体结构完整。结论 硒可以通过提高机体的抗氧化能力来延缓神经细胞和线粒体老化
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| 关 键 词： | 硒 神经细胞 线粒体 D-半乳糖 衰老 |
| 文章编号： | 1001-0580(2002)07-0769-02 |
| 修稿时间： | 2001-05-21 |
Protective Effects of Selenium on Neuron and Mitochondria of Senile Mice |
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| GAO Liang cai,CHEN Wan rong,FU Zhong dian,et al.. Protective Effects of Selenium on Neuron and Mitochondria of Senile Mice[J]. Chinese Journal of Public Health, 2002, 18(7): 769-770 |
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| Authors: | GAO Liang cai CHEN Wan rong FU Zhong dian et al. |
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| Affiliation: | GAO Liang cai,CHEN Wan rong,FU Zhong dian,et al.East China Normal University |
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| Abstract: | Objective To investigate the effects of selenium on neuron and mitochondria of senile mice.Methods Using D-galactose induced aging model,the activities of SOD,GSH-Px,MAO-B and levels of MDA,GSH in brain were measured.The changes of LPF and mitochondria were observed by using transmission electron microscope.Results Selenium can obviously enhance the activities of SOD and GSH-Px,increase the level of GSH,decrease the levels of LPF and MDA,inhabit the activity of MAO and protect the mitochondria from being destroyed.Conclusion Selenium can raise the antioxidation ability of mouse brain and delay the aging of neuron and mitochondria. |
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| Keywords: | selenium neuron mitochondria D-galactose aging |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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