氟伐他汀治疗早期糖尿病肾病疗效分析

目的　探讨氟伐他汀治疗糖尿病肾病 (DN)的疗效及其抗炎机制。方法　选择 2 0 0 0 - 0 2～ 2 0 0 3- 0 6广东省东莞市人民医院门诊及住院的 14 0例早期DN患者随机分为治疗组和对照组。对照组给予常规治疗 ,治疗组每晚加服氟伐他汀 4 0mg。比较两组治疗前及治疗后 3、6、9个月的尿白蛋白排泄率 (UAER)、血肌酐 (Scr)和反应蛋白 (CRP)等指标。结果　治疗组UAER和Scr下降比对照组明显 (P <0 0 5 ,P <0 0 1) ,起效更快 (早 3个月 ) ;治疗组CRP明显下降 (P <0 0 5 ,P <0 0 1) ,而对照组CRP下降不明显 (P >0 0 5 )。而且 ,对两组中血脂正常的DN患者进行比较分析也得出类似的结果。结论　氟伐他汀因降低CRP的抗炎效应而减轻微量白蛋白尿和改善肾功能 ,该作用不依赖氟伐他汀的降血脂效应

Curative effects of fluvastatin in early diabetic nephropathy

Objective To investigate the curative effects of fluvastatin and its anti-inflammation mechanism in early diabetic nephropathy (EDN).Methods 140 patients with EDN were randomly divided into two groups,the control group (n=70) and the treated group (n=70).The control group received conventional therapy,while the treated group was added oral 40 microgram of fluvastatin every night.Compare the UAER,Scr and CRP 3,6 and 9 months later respectively.Results UAER and Scr had been decreased more significantly and quickly(three months earlier) in treated group than in control group. CRP had been decreased significantly in treated group,while no significant decrease had been found in control group during the follow-up of nine months.Furthermore,similar results were also obtained in those EDN with normolipidemia when further analyzed.Conclusion Fluvastatin can ameliorate microalbuminuria and improve renal function by its anti-inflammation effect by decreasing CRP,which is independent of its lowering lipidemia effect.