幼年雄性大鼠双侧睾丸切除后体内Na~＋、K~＋－ATP酶活性的动态观察

采用雄性大鼠６４只作为研究对象，实验组６周龄时切除双侧睾丸，同时设对照组。分别于术后１、３、６和９个月收集标本，测定Ｎａ￣＋Ｋ￣＋－ＡＴＰ酶活性和血浆睾酮含量。结果表明：（１）去双侧睾丸后红细胞膜Ｎａ￣＋Ｋ￣＋－ＡＴＰ酶活性明显低于同月龄正常对照组（Ｐ＜０．０１）；并且随去睾月龄的增加，去睾组红细胞膜Ｎａ＋Ｋ＋－ＡＴＰ酶活性无明显上升。大鼠红细胞膜Ｎａ＋Ｋ＋－ＡＴＰ酶活性的高低与血浆睾酮含量呈直线相关（ｒ＝０．９４），表明雄激素对雄性动物的Ｎａ＋Ｋ＋－ＡＴＰ酶活性具有兴奋作用。

A successive obervation of Na K ATPase activity in male immature castrated rats

male rats were studied. Half of them were castrated biliteraly at 6 weeks of age and the rest served as controls. Samples were collected on the 1st, 3rd, 6th and 9th month after castration. The activity of Na K ATPase in erythroryte membrane and the concentration of serum testosterone were assaied. The results showed that the activity of Na K ATPase in the castrated rats was much lower than that in un-castrated rats (P<0.01) and failed to elevate with increatse of age after castration. It was also found that the activity of Na K ATPase was correlated strongly with the level of serum testosterone in male rats (r=0.938) denoting that androgen might stimulate the activity of Na K ATPase in erythrocyte membrane in male rats.