A型肉毒毒素治疗面肌及眼睑痉挛

目的观察A型肉毒毒素治疗面肌和眼睑痉挛的疗效。方法对168例面肌及12例眼睑痉挛患者进行眼面部痉挛肌肉局部多点注射A型肉毒毒素，评价治疗效果。结果180例面肌及眼睑痉挛患者，完全缓解率67.8%、明显缓解率22.8%、部分缓解率9.4%，总有效率达100%；起效时间1～7d，疗效持续时间在面肌痉挛和眼睑痉挛分别为(14.6±4.7)和(13.4±5.4)周。局部不良反应轻微、短暂，无全身反应及过敏反应。结论A型肉毒毒素局部注射是治疗面肌及眼睑痉挛的一种安全、有效、简便、易行的治疗方法。

Efficacy of botulinumtoxin A in the treatment of hemifacial spasm and blepharospasm

Objective:To investigate the efficacy of botulinum t oxin A in the treatment of hemifacial spasm and blepharospasm.Methods:Patients with hemifacial spasm(n=168) and blepharospasm (n=12) were t reated with botulinum toxin A given by local injection on multiple sites and the efficacy was observed.Results:A complete relief rate of 67.6%,an obvious relief rate of 22.6%,and a partial relief rate of 9.4% were obtained in all patients with a total effective rate of 100%.The onset of action of the dru g was 1～7 day and lasted for (14.6±4.7) weeks for hemifacial spasm and (13.4± 5.4) weeks for blepharospasm with mild and transient side-effects.Concl usion:Botulinum toxin A given by local injection on multiple sites is effe ctive in treatment of hemifacial spasm and blepharospasm.