| 人脂肪干细胞在骨组织工程中应用的研究进展 |
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| 引用本文： | 程海兵,董佳生. 人脂肪干细胞在骨组织工程中应用的研究进展[J]. 组织工程与重建外科, 2011, 7(4): 231-234 |
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| 作者姓名： | 程海兵 董佳生 |
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| 作者单位： | 上海交通大学医学院附属第九人民医院整复外科; |
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| 基金项目： | 上海市自然科学基金(044119617) |
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| 摘 要： | 大面积骨缺损的修复一直是临床面临的难题。近年来，干细胞和骨组织工程研究的不断深人，为临床骨缺损的修复提供了新的思路。脂肪干细胞（Adipose—derivedstemcell，ADSC）由于来源丰富且容易获取，体内、外实验均证实其能分化形成骨样组织，已成为骨组织工程的重要的种子细胞来源。本文就hADSC的免疫表型、体内成骨、成骨分化的调控及骨形态发生蛋白2（Bonemorphogenetic protein-2，BMP2）对hADSC成骨分化的影响进行综述。
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| 关 键 词： | 人脂肪干细胞 骨组织工程 成骨分化调控 骨形态发生蛋白2 |
The Application of Human Adipose-Derived Stem Cells in Bone Tissue Engineering |
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| CHENG Haibing,DONG Jiasheng. The Application of Human Adipose-Derived Stem Cells in Bone Tissue Engineering[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2011, 7(4): 231-234 |
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| Authors: | CHENG Haibing DONG Jiasheng |
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| Affiliation: | .Department of Plastic and Reconstruction Surgery,Shanghai Ninth People′s Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China. |
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| Abstract: | The reconstruction of large bone defects has been an important issue in clinical practice.Recently,bone tissue engineering combining with stem cell has emerged as one of the most promising therapeutic modality for clinical use.Human adipose-derived stem cell(hADSC) have now considered to be a promising stem cell source in bone tissue engineering,mainly due to its wide availability,easy access and the ability of osteogenesis both in vitro and vivo.This review aims to characterize human ADSC based on its surf... |
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| Keywords: | Human adipose-derived stem cells Bone tissue engineering Regulation of osteogenesis Bone morphogenetic protein-2 |
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