Antimicrobial activity of innate immune molecules against <Emphasis Type="Italic">Streptococcus pneumoniae,Moraxella catarrhalis</Emphasis> and nontypeable <Emphasis Type="Italic">Haemophilus influenzae</Emphasis> |
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| Authors: | Haa-Yung?Lee Ali?Andalibi Paul?Webster Sung-Kyun?Moon Karen?Teufert Sung-Ho?Kang Jian-Dong?Li Mitsuyoshi?Nagura Tomas?Ganz Email author" target="_blank">David?J?LimEmail author |
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| Institution: | (1) The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California 90057, USA;(2) Ahmanson Center for Advanced Electron Microscopy, House Ear Institute, Los Angeles, California 90057, USA;(3) Department of Otolaryngology, University of Southern California, Los Angeles, California 90033, USA;(4) Department of Cell and Neurobiology, University of Southern California, Los Angeles, California 90033, USA;(5) Department of Medicine, University of California, Los Angeles, California 90024, USA;(6) Departments of Otolaryngology, Ajou University School of Medicine, Suwon, Korea;(7) Department of Otolaryngology and Head & Neck Surgery, School of Medicine, KonKuk University Hospital, Chungju, Korea;(8) Department of Otorhinolaryngology, Hamamatsu University School of Medicine, Hamamatsu, Japan |
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| Abstract: | Background Despite its direct connection to the nasopharynx which harbors otitis media pathogens as part of its normal flora, the middle
ear cavity is kept free of these bacteria by as yet unknown mechanisms. Respiratory mucosal epithelia, including those of
the middle ear and eustachian tube, secrete antimicrobial effectors including lysozyme, lactoferrin and β defensins-1 and
-2. To elucidate the role of these innate immune molecules in the normal defense and maintenance of sterility of respiratory
mucosa such as that of the middle ear, we assessed their effect on the respiratory pathogens nontypeable Haemophilus influenzae (NTHi) 12, Moraxella catarrhalis 035E, and Streptococcus pneumoniae 3, and 6B. |
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