乙型肝炎相关性肝细胞肝癌HBV血清标志物特征探讨

目的探讨乙型肝炎相关性肝细胞肝癌（HCC）乙型肝炎病毒（HBV）血清标志物特征。方法选择2009年6月~2013年6月临床确诊的有明确HBV感染史的HCC患者312例,分析患者HBV DNA载量,定量检测HBV标志物（包括HBsAg、HBsAb、HBeAg、HBeAb、HBcAb）并分析其组合方式。结果①312例HCC患者中,HBV DNA阳性299例（299/312,95.83%）。HBeAg阳性者41例（41/312,13.14%）,其HBV DNA载量为（5.79±2.53）Log10copies/ml;HBeAg阴性者271例（271/312,86.86%）,其HBV DNA载量为（4.59±1.66）Log10copies/ml（P〈0.01）。②HBV标志物存在6种组合方式,6.09%患者HBsAg阴性,86.86%患者HBeAg阴性。结论 HBV DNA多为低至中等水平,HBV DNA阳性者中高病毒载量者仅为少数;HBeAg阴性者远多于HBeAg阳性者;HBsAg滴度较低,少数患者HBsAg阴性。

Characteristic of hepatitis B related hepatocellular carcinoma HBV serum markers

Objective To investigate the characteristic between hepatitis B virus（HBV） chronic infection and hepatocellular carcinoma（HCC）.Methods Selected 312 HCC patients with a clear history of hepatitis B from Jun 2009 to Jun2013.Analyzed the serum level of HBV DNA,detected quantificationally HBV markers and analyzed the compound mode.Results ① Among all 312 HCC patients,the positive rate of HBV DNA was 95.83%,the positive rate of HBeAg was 13.14%,and the serum HBV DNA level was（5.79±2.53） Log10copies/ml,271 patients were HBeAg negative,and the HBV DNA level was（4.59±1.66） Log10copies/ml.② There were 6 compound mode of serum HBV markers.6.09% of the patients were HBsAg negative and 86.86% of the patients were HBeAg negative.Conclusion In all the cases of HBV related HCC,the serum HBV DNA load is mostly low to medium level,there are more patients with negative HBeAg than those with positive HBeAg,while the HBsAg titer is at a low level.