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乙型肝炎表面抗原阳性血吸虫病患者 HDV 感染的血清学及预后调查
引用本文:骆名其,桂稀恩,高世成,杨自成,唐翠娥. 乙型肝炎表面抗原阳性血吸虫病患者 HDV 感染的血清学及预后调查[J]. 中国病原生物学杂志, 1997, 0(2)
作者姓名:骆名其  桂稀恩  高世成  杨自成  唐翠娥
作者单位:湖北医科大学附属第二医院传染科
摘    要:用酶联免疫吸附试验(ELISA)检测123例乙型肝炎表面抗原(HBsAg)阳性的各期血吸虫病患者及50例HBsAg阳性的非血吸虫病对照人群血清丁型肝炎病毒(HDV)标志物,用斑点杂交检测晚期血吸虫病(晚血,AS)患者HBV-DNA。结果表明,HBsAg阳性的晚血患者HDV标志物(HDV-M)检出率14.5%,显著高于急性血吸虫病(急血)、慢性血吸虫病(慢血)患者(2.5%)及对照人群(2.0%)(P<0.05)。随访观察发现,HBV/HDV双重感染的晚血患者病死率40%,显著高于单纯HBV感染的晚血患者(8.5%,P<0.05),提示晚血患者是HDV感染的易感人群,HDV感染是HBsAg阳性晚血患者病情加重或恶化的一个重要原因,HBV/HDV双重感染与晚血患者死亡密切相关。

关 键 词:血吸虫病  乙型肝炎病毒  丁型肝炎病毒  合并感染

STUDIES ON HBV AND HDV COINFECTION IN PATIENTS WITH SCHISTOSOMIASIS
Luo Ming-Qi,Gui Xi-En,Gao Shi-Cheng,Yang Zi-Cheng,Tang Cui-E. STUDIES ON HBV AND HDV COINFECTION IN PATIENTS WITH SCHISTOSOMIASIS[J]. Journal of Pathogen Biology, 1997, 0(2)
Authors:Luo Ming-Qi  Gui Xi-En  Gao Shi-Cheng  Yang Zi-Cheng  Tang Cui-E
Affiliation:Wuhan 430071
Abstract:In order to investigate the HDV infection among patients with schistosomiasis, serum HDV markers were tested in 123 HBsAg- positive patients with schistosomiasis and 50 HBsAg- carriers without schistosomiasis. HBV-DNA was tested in 69 HBsAg-positive patients with advanced schistosomiasis(AS) using Dot- blot Hybridization technique. The results showed that the positive rate of HDV markers among patients with AS(14.5%) was significantly higher than that of acute(0%), chronic schistosomiasis(2.5%) and the control group(2.0%). The death rate of patients coinfected with HBV and HDV was significantly greater than that of AS patients infected with HBV alone. The results suggested that patients with AS were at high risk of HDV infection. HBV and HDV coinfection may play a crucial role in the death of patients with AS. It is important to improve the preventive measures and therapy of viral hepatitis in the endemic area of schistosomiasis .
Keywords:Schistosomiasis   HBV   HDV   coinfection
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