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| 链脲佐菌素诱导糖尿病大鼠血、尿渗透压的变化 | |
| 引用本文： | 白利萍,杜娟,魏丽晶. 链脲佐菌素诱导糖尿病大鼠血、尿渗透压的变化[J]. 中国实验诊断学, 2007, 11(6): 732-733 |
| 作者姓名： | 白利萍 杜娟 魏丽晶 |
| 作者单位： | 1. 长春中医学院,新药中心,吉林,长春,130021 2. 重庆医科大学附属第一医院,内分泌科 3. 吉林大学第一附属医院,检验科 |
| 摘 要： | 目的 测定糖尿病（diabetes mellitus,DM）大鼠血、尿渗透压的改变并讨论其在糖尿病肾病（DN）早期诊断中的意义。方法 以链脲佐菌素（strap tozocin,STZ）诱导大鼠制成DM动物模型,分为糖尿病组（DM组）和正常对照组（Con组）,在成模后3星期,用生化自动分析仪测定其血渗透压,采用冰点法测定尿渗透压,组间数据比较采用t检验。结果 0星期时DM组与Con组比较体重无差异,3星期时DM组体重明显低于Con组,尿量高于Con）,相对肾重高于Con组,二组间CRE无明显变化。最大尿浓缩渗透压DM组低于Con组（P〈0.05）,血渗透压DM组高于Con组（P〈0.05）。结论 尿渗透压可作为DN早期诊断的辅助指标。 |
| 关 键 词： | 糖尿病肾病 链脲佐菌素 血渗透压 尿渗透压 |
| 文章编号： | 1007-4287（2007）06-0732-02 |
| 修稿时间： | 2005-11-07 |
The changes of urinary osmolalities and plasma osmolalities in diabetic rats induced by STZ |
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| BAI Li-ping,DU Juan,WEI Li-jing. The changes of urinary osmolalities and plasma osmolalities in diabetic rats induced by STZ[J]. Chinese Journal of Laboratory Diagnosis, 2007, 11(6): 732-733 | |
| Authors: | BAI Li-ping DU Juan WEI Li-jing |
| Affiliation: | College of Traditional Chinese Medicine, Changchun 1313021, China |
| Abstract: | Objective To measure the urinary osmolalities and plasma osmolalitiesin diabetes mellitus(DM) rats induced by STZ and discuss their significence in diabetic nephropathy(DN).Methods The present study included experimental group(DM group) and control healthy group(Con group).The urinay osmolalities and plasma osmolalities were measured by freezing point depression osmometer.Results The urinay osmolalities of DM group were lower than that of Con group(P<0.05).The plasma osmolalities of DM group were higher than that of Con group(P<0.05).Conclusion The urinay osmomalities might be a sensitive maker for the early diagnosis of DN. |
| Keywords: | Diabetic nephropathy Strap tozocin Ufinay osmolalities Plasma osmolalities |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |