| 调肝运脾方对腹泻型肠易激综合征患者脑内兴奋区域MR信号强度变化幅度的影响 |
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| 引用本文： | 霍清萍,张仲伟,李金菩,王宇新,梁芳. 调肝运脾方对腹泻型肠易激综合征患者脑内兴奋区域MR信号强度变化幅度的影响[J]. 浙江中医药大学学报, 2008, 32(5) |
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| 作者姓名： | 霍清萍 张仲伟 李金菩 王宇新 梁芳 |
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| 作者单位： | 1. 上海交通大学附属第六人民医院,上海,200233
2. 上海交通大学附属瑞金医院 |
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| 基金项目： | 上海市卫生局资助项目 |
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| 摘 要： | [目的]探讨中药调肝运脾方对腹泻型肠易激综合征（IBS）患者脑内兴奋区域MR信号强度变化幅度的影响。[方法]采用自身对照方法，运用功能磁共振成像（fMRI）技术分别观察18例腹泻型IBS患者治疗前后及对照用药后在不同容量直肠气囊刺激时脑内扣带回前皮层（ACC）、脑岛皮层（IC）、前额叶皮层（PFC）和丘脑（THAL）兴奋区域MR信号强度变化幅度。[结果]注气为量90ml时，IC兴奋区域MR信号强度变化幅度治疗后较治疗前显著降低，P〈0．05。注气量为120ml时，IC、PFC和THAI。兴奋区域MR信号强度变化幅度治疗后均较治疗前显著降低，P〈0．05；IC兴奋区域MR信号强度变化幅度较对照后也呈显著降低，P〈0．05。[结论]调肝运脾方对IBS患者脑肠轴及其调节机制功能紊乱的干预，与其抑制IBS患者脑内IC、PFC和THAL兴奋区域激活程度有关。
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| 关 键 词： | 肠易激综合征 调肝运脾方 脑肠轴 MR信号强度变化幅度 |
The Influence of Tiao-gan-yun-pi Decoction on the Regional Encephalic Activation of MR Signal Intensity Variation among Diarrhea Type Irritable Bowel Syndrome Patients |
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| Huo Qingping,Zhang Zhongwei,Li Jinpu,et al Shanghai No. People's Hospital,Shanghai Jiaotong University,Shanghai Ruijin Hospital,Shanghai Jiaotong University. The Influence of Tiao-gan-yun-pi Decoction on the Regional Encephalic Activation of MR Signal Intensity Variation among Diarrhea Type Irritable Bowel Syndrome Patients[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2008, 32(5) |
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| Authors: | Huo Qingping Zhang Zhongwei Li Jinpu et al Shanghai No. People's Hospital Shanghai Jiaotong University Shanghai Ruijin Hospital Shanghai Jiaotong University |
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| Affiliation: | Huo Qingping,Zhang Zhongwei,Li Jinpu,et al Shanghai No.6 People's Hospital,Shanghai Jiaotong University(200233),Shanghai Ruijin Hospital,Shanghai Jiaotong University |
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| Abstract: | To investigate the Tiao-gan-yun-pi decoction on the region of exciting regional encephalic activation MR signal intensity variation among Diarrhea Type Irritable Bowel Syndrome patients.[Method] Using self-paired collated method,we used functional fMRI to observe the arear region of exciting MR signal intensity variation of anterior cingulate cortex(ACC),Island cortex(IC),Prefrontal cortex(PFC),Hypothalamus(THAL) before and after the treatment,as well as after the controlled treatment using placebo among 18... |
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| Keywords: | Irritable Bowel Syndrome Tiao-gan-yun-pi decoction Brain-Gut axis MR signal intensity variation |
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