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载脂蛋白E基因多态性与早发冠心病的关系及其对血脂的影响
引用本文:彭澍,彭健,龚五星. 载脂蛋白E基因多态性与早发冠心病的关系及其对血脂的影响[J]. 中华医学遗传学杂志, 2001, 18(5): 375-378
作者姓名:彭澍  彭健  龚五星
作者单位:暨南大学医学院第三附属医院珠海市人民医院
基金项目:广东省医学科研立项资助课题(1998567)
摘    要:目的 研究载脂蛋白E(apolipoprotein E,apoE)基因多态性与早发冠心病(coronary heart disease,CHD)的相关关系及其对血脂水平的影响。方法 应用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restricted fragment hength polymorphism,PCR-RFLP)基因分析方法,测定52例早发CHD、161例迟发CHD患者和180名对照者的apoE基因型;血脂水平按常规方法测定。结果 发现的5种apoE基因型,分别为E3/3、E4/4、E3/2、E4/3及E4/2。早发CHD组和迟发CHD组apoE4/3基因型和ε4等位基因频率均高于对照组(P<0.01);进一步对两组CHD患者的apoE多态性进行分析,发现早发组ε4等位基因频率较迟发组为高(P<0.05)。apoE各等位基因型之间,TC和LDL-C水平之间存在统计学差异(P<0.05)。结论 apoE基因多态性与早发CHD的发生发展有关并影响血脂的水平。

关 键 词:冠心病 载脂蛋白E基因 多态性 血脂质水平
修稿时间:2000-12-13

Association of apolipoprotein E gene polymorphism with early-onset coronary heart disease and its effect on plasma lipid levels
PENG Shu,PENG Jian,GONG Wuxing.. Association of apolipoprotein E gene polymorphism with early-onset coronary heart disease and its effect on plasma lipid levels[J]. Chinese journal of medical genetics, 2001, 18(5): 375-378
Authors:PENG Shu  PENG Jian  GONG Wuxing.
Affiliation:Zhuhai People's Hospital, The Third Affiliated Hospital of Jinan University, Zhuhai, Guangdong, 519000 P.R. China. peng_shu@163.net
Abstract:OBJECTIVE: To detect the association of apolipoprotein E(apoE) gene polymorphism with early-onset coronary heart disease(CHD) and to evaluate the effect of apoE gene polymorphism on plasma lipid levels. METHODS: The apoE genotypes of 52 early-onset CHD patients (aged 38-55 years), 161 aged CHD patients and 180 controls were determined by PCR-RFLP. Plasma lipid levels were measured by using routine methods. RESULTS: Five genotypes of apoE, E3/3, E4/4, E3/2, E4/3 and E4/2 were detected in this study. Statistically differences in apoE4/3 and epsilon4 frequencies between early-onset and aged CHD patients and controls were seen (P<0.05). The frequency of epsilon4 in the early-onset CHD patients was higher than that in the aged CHD patients. epsilon4 and epsilon2 alleles also differently affected the plasma total cholesterol and low density lipoprotein cholesterol levels. CONCLUSION: These results suggest that apoE gene polymorphism is in association with the occurrence and development of early-onset CHD and it affects the plasma lipid levels.
Keywords:coronary heart disease  apolipoprotein  E gene  polymorphism  plasma lipid level
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