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P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis |
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| Authors: | Anthony J Sharp Paul E Polak Vittoria Simonini Shao X Lin Jill C Richardson Ernesto R Bongarzone Douglas L Feinstein |
| Institution: | (1) Department of Anesthesiology, University of Illinois, Chicago, IL 60612, USA;(2) Jesse Brown Veteran's Affairs Research Division, Chicago, IL 60612, USA;(3) GlaxoSmithKline Pharmaceuticals, Harlow, UK;(4) Department of Cell Biology and Anatomy, University of Illinois, Chicago, IL 60612, USA |
| Abstract: | BackgroundThe purinergic receptor P2x7 is expressed on myeloid cells as well as on CNS glial cells, and P2x7 activation has been shown to increase both glial and T-cell activation. These properties suggest a role in the development of autoimmune disease including multiple sclerosis. |
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