Multiple interactions between the alpha2C- and beta1-adrenergic receptors influence heart failure survival |
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| Authors: | Sharon LR Kardia,Reagan J Kelly,Mehdi A Keddache,Bruce J Aronow,Gregory A Grabowski,Harvey S Hahn,Karen L Case,Lynne E Wagoner,Gerald W Dorn Suffix" >II,Stephen B Liggett |
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| Affiliation: | (1) Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St, 48109-2029 Ann Arbor, MI, USA;(2) Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA;(3) Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA;(4) Center for Pharmacogenomics, Washington University School of Medicine, St Louis, 63110, MO, USA;(5) Department of Medicine, Cardiopulmonary Genomics Program, University of Maryland, 20 Penn St., HSF-II, 21201-1075 Baltimore, MD, USA |
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| Abstract: | Background Persistent stimulation of cardiac β1-adrenergic receptors by endogenous norepinephrine promotes heart failure progression. Polymorphisms of this gene are known to alter receptor function or expression, as are polymorphisms of the α2C-adrenergic receptor, which regulates norepinephrine release from cardiac presynaptic nerves. The purpose of this study was to investigate possible synergistic effects of polymorphisms of these two intronless genes (ADRB1 and ADRA2C, respectively) on the risk of death/transplant in heart failure patients. |
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