| 类肝素聚乙烯醇复合材料抗凝血性能的研究 |
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| 引用本文： | 李沁华,邹翰. 类肝素聚乙烯醇复合材料抗凝血性能的研究[J]. 中国生物医学工程学报, 1999, 18(1): 15-21 |
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| 作者姓名： | 李沁华 邹翰 |
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| 作者单位： | 暨南大学生物医学工程研究所,广州,510632 |
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| 摘 要： | 本文报道了聚乙烯醇羧甲醚（ＰＣ）、聚乙烯醇硫酸酯（ＰＳ）及聚乙烯醇接枝甲基丙烯酸β羟乙酯、丙烯腈（ＰＶＡｇＨＥＭＡＡＮ）的合成制备方法。通过红外光谱和元素分析定性、定量证实了合成方法的可行性。研究了将ＰＣ、ＰＳ以不同重量比加入ＰＶＡｇＨＥＭＡＡＮ后形成的聚乙烯醇衍生物复合材料（ＣＤＰＶＡ）对抗凝血性能的影响。（ＣＤＰＶＡ）对人血的溶血度仅为３２％，人血复钙时间比空白对照延长２０２ｓ，凝血时间延长１８５７ｓ。ＳＥＭ观察表明ＣＤＰＶＡ接触血液一定时间后表面没有形成血液蛋白纤维网络，具有微相分离结构。
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| 关 键 词： | 聚乙烯醇羧甲醚（PC），聚乙烯醇硫酸酯（PS），聚乙烯醇-甲基丙烯酸β-羟乙酯-丙烯腈（PVA-g-HEMA-AN），聚乙烯醇衍生物复合材料（CD-PVA），血液相溶性，抗凝血性 |
STUDIES ON LIKE HEPARIN OF PVA BLENDS ANTITHROMBIN |
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| Li Qinhua,Zou Han. STUDIES ON LIKE HEPARIN OF PVA BLENDS ANTITHROMBIN[J]. Chinese Journal of Biomedical Engineering, 1999, 18(1): 15-21 |
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| Authors: | Li Qinhua Zou Han |
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| Abstract: | We reported the synthesis methods of sulfated PVA, carboxymethy1 PVA and PVA g HEMA AN. The degrees of sulfatnation was 45.5% and The degrees of carboxymethylnation was 16.07% in PVA. The weight percentage of PVA was 61.2%, HEMA,28.76% and AN, 10.03% in PVA g HEMA AN. A series of experiments were done to determine the blood compatibility of blends material. WBCT was prolongated 1857sec and plasma recalification time was prolongated 202sec as compared with contrast sample. SEM showed that fibrin network was not found in blends material and microphase separation was obtained. The blends material water content was higher. |
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| Keywords: | Sulfated PVA Carboxymethyl PVA PVA g HEMA AN CD PVA Blood compatibility Antithrombin |
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