c-erb-B_2、P_(53)癌基因蛋白在消化道癌症中的表达及其与癌组织微血管周围纤维连接蛋白的关系

用免疫组织化学标记法测定27例消化道癌症病人c-erb-B_2、P_(53)癌基因蛋白的表达。胃癌组(n=17)c-erb-B_2阳性率为70.59％,炎症溃疡对照组(n=9),阳性率为44.44％,健康人组(n=4)阳性率为0％。胃癌转移组(n=6)P_(53)表达的阳性率(0％)比胃癌无转移组(n=11)阳性率(54.55％)明显降低(P<0.05)。在两种癌基因的联合表达上,以c-erb-B_2( )P_(53)(-)组最多(52.94％)。6例有转移的胃癌中癌组织间质微血管周围的Fn免疫荧光明显减弱,与c-erb-B_2表达间呈明显负相关(r=-0.8728,P<0.05)。重点讨论了上述变化与胃癌间的可能关系。

Expression of c-erb-B2,P53 Oncoproteins in Digestive Tract Cancers and Its Correlation with Fibronectin

Using the immunohistochemical method, we analysed the expression of c-erb-B2 and P53 onco-proteins in 27 cases of digestive tract cancers. Strong stain of c-erb-B2 was found in 70. 5% of stomach cancer patients (n=17),in 44.44% of gastritis and ulcer patients (n = 9), no positive stain of c-erb-B2 was seen in healthy subjects (n = 4). The positive rate of P53 expression in stomach cancer with metastasis (0%) was significantly different from that in stomach cancer without metastasis (54. 55%). In the 52. 9% of cases of stomach cancer, positive stain of c-erb-B2 was in coexpression with negative stain of PS3. In the tissue of stomach cancer with metastasis, the Fn immunofluorescence around microvessels was very slight. There was a negative correlation between scores of Fn immunofluorescence and c-erb-B2 oncoprotein expression (r = -0. 8728,P <0. 05). The probable relationship between above changes and gastric cancers was discussed in this paper.