牙周炎患者口腔中的幽门螺杆菌

目的初步探讨牙周炎患者口腔中的幽门螺杆菌（helicobacter pylori，HP）与牙周炎的关系。方法依据Hp特异的尿素酶C和cagA基因设计引物，建立PCR方法。检测37例牙周炎患者口腔中的Hp，同时设立牙周健康对照组，比较两组的检测结果。结果尿素酶C基因在牙周炎组的阳性率为64．8％，健康组为38．5％；尿素酶C基因和cagA基因共同阳性率在牙周炎组为32．4％，健康组为7．7％；两组差异有统计学意义；且轻型牙周炎患者口腔Hp阳性率低于中、重型患者。龈下菌班Hp阳性率高于龈上菌班。结论口腔是Hp的一个重要聚积地，Hp与牙周炎有相关性。

Helicobacter pylori in mouths of patients with periodontitis

Objective: To investigate the relationship between Helicobacter pylori (Hp) and periodontitis.Methods: A polymerase chain reaction(PCR) assay with oligonucleotide primers homologous to a portion of the urease C and cytotoxin-associated gene A(cagA) of Hp was used to test for the presence of Hp in dental plaque.Thirty-seven patients with periodontitis and 38 healthy persons were studied to compare the results of the two groups.Results: In the periodontitis group,64.8%of the tested samples was ureasc gene positive,and 32.4% was positive for both urease C and cagA genes.In healthy persons,38.5% of the tested samples was urease C gene positive and 7.7% was positive for both urease C and cagA genes.There was a significantly difference between the two groups(P<0.01).The Hp-positive rate of the major periodontitis was enhanced obviously to minor peciodontitis.The Hp-positive rate of subgingival plaque was significantly higher than that of supragingival plague.Conclusion: These results suggest that oral cavity is an ecological micle of Hp.