Two new lignans fromLindera obtusiloba blume |
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Authors: | Hak Cheol Kwon Sang Un Choi Jung Ock Lee Ki Hwan Bae Ok Pyo Zee Kang Ro Lee |
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Affiliation: | Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea. |
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Abstract: | Two new furanolignans (3, 5), together with three known lignans (1, 2, 4), were isolated from the stem of Lindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol (5) on the basis of physicochemical and spectroscopic evidences. Compounds 1, 2, 3, and 5 showed cytotoxicity against a small panel of human tumor cell lines with ED50 values of 3.40 to approximately 19.27 microg/ml. |
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Keywords: | Lindera obtusiloba Lauraceae Cytotoxicity Lignan Actifolin Pluviatilol |
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